Abstract
1 Prostaglandin E1 and bradykinin exert synergistic effects on vascular permeability in rat skin and in rat paws. Prostaglandin E2 is inactive in this respect.
2 Prostaglandin F2α reduces the bradykinin response in rat skin but not in rat paws. It also markedly reduces the response of the skin to dextran, 5-hydroxytryptamine and histamine.
3 Prostaglandin E1 and dextran exert synergistic effects in rat skin when threshold doses of each agent are used.
4 Rats genetically resistant to dextran fail to respond to intradermal dextran in the presence of prostaglandin E1.
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Selected References
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