Abstract
1 In the baboon the blood levels of pentazocine between 1 and 60 min after intravenous injection of 0.5 mg/kg were measured by a gas chromatographic technique. From cerebral arteriovenous differences it was shown that the peak of the brain concentration occurred within 15 min and probably within 10 min of intravenous injection. At the time of peak concentration about 10% of the injected dose was in the brain, while the corresponding value at 60 min was 2%.
2 The concentration of pentazocine in the brain was an order of magnitude greater than the concentration in cerebral venous blood both at 5 min and 60 min after injection. No major brain interregional differences were demonstrated. Cerebrospinal fluid from the cisterna magna did not yield values from which the cerebral concentration of pentazocine could be predicted.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Beckett A. H., Taylor J. F., Kourounakis P. The absorption, distribution and excretion of pentazocine in man after oral and intravenous administration. J Pharm Pharmacol. 1970 Feb;22(2):123–128. doi: 10.1111/j.2042-7158.1970.tb08404.x. [DOI] [PubMed] [Google Scholar]
- Berkowitz B. A., Asling J. H., Shnider S. M., Way E. L. Relationship of pentazocine plasma levels to pharmacological activity in man. Clin Pharmacol Ther. 1969 May-Jun;10(3):320–328. doi: 10.1002/cpt1969103320. [DOI] [PubMed] [Google Scholar]
- Berkowitz B. A., Way E. L. Analgesic activity and central nervous system distribution of the optical isomers of pentazocine in the rat. J Pharmacol Exp Ther. 1971 Jun;177(3):500–508. [PubMed] [Google Scholar]
- Coroneos N. J., McDowall D. G., Gibson R. M., Pickerodt V. W., Keaney N. P. Measurement of extradural pressure and its relationship to other intracranial pressures. An experimental and clinical study. J Neurol Neurosurg Psychiatry. 1973 Aug;36(4):514–522. doi: 10.1136/jnnp.36.4.514. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Scott M. E., Adgey A. A. Circulatory effects of intravenous pentazocine in patients with acute myocardial infarction. Curr Ther Res Clin Exp. 1971 Feb;13(2):81–89. [PubMed] [Google Scholar]