Skip to main content
British Journal of Pharmacology logoLink to British Journal of Pharmacology
letter
. 1974 Mar;50(3):425–427. doi: 10.1111/j.1476-5381.1974.tb09619.x

Antagonism by folic acid of presynaptic inhibition in the rat cuneate nucleus

RG Hill, AA Miller
PMCID: PMC1776696  PMID: 4850584

Abstract

Folic acid applied topically in solution to the rat cuneate nucleus reduced presynaptic inhibition produced by peripheral stimulation. This resembles the action of picrotoxin in the same animals and it is possible that these two convulsants are acting in a similar manner by blockade of the receptors for the presynaptic inhibitory transmitter.

Full text

PDF
425

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Banna N. R., Jabbur S. J. Pharmacological studies on inhibition in the cuneate nucleus of the cat. Int J Neuropharmacol. 1969 May;8(3):299–307. doi: 10.1016/0028-3908(69)90051-3. [DOI] [PubMed] [Google Scholar]
  2. Baxter M. G., Miller A. A., Webster R. A. Some studies on the convulsant action of folic acid. Br J Pharmacol. 1973 Jun;48(2):350P–351P. [PMC free article] [PubMed] [Google Scholar]
  3. Davidson N., Southwick C. A. Amino acids and presynaptic inhibition in the rat cuneate nucleus. J Physiol. 1971 Dec;219(3):689–708. doi: 10.1113/jphysiol.1971.sp009683. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Davies J., Watkins J. C. Facilitatory and direct excitatory effects of folate and folinate on single neurones of cat cerebral cortex. Biochem Pharmacol. 1973 Jul 1;22(13):1667–1668. doi: 10.1016/0006-2952(73)90034-8. [DOI] [PubMed] [Google Scholar]
  5. Hommes O. R., Obbens E. A. The epileptogenic action of Na-folate in the rat. J Neurol Sci. 1972 Jul;16(3):271–281. doi: 10.1016/0022-510x(72)90192-x. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES