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. 1974 Apr;50(4):525–529. doi: 10.1111/j.1476-5381.1974.tb08585.x

Distribution of α- and β-adrenoceptors in human urinary bladder

SA Awad, AW Bruce, G Carro-Ciampi, JW Downie, M Lin, GS Marks
PMCID: PMC1776723  PMID: 4447856

Abstract

1 The distribution of α- and β-adrenoceptors in isolated preparations of human bladder neck and detrusor muscle has been studied.

2 Adrenaline caused contraction of the bladder neck which was blocked by phenoxybenzamine but unaltered by propranolol.

3 Isoprenaline caused relaxation of the bladder neck which was blocked by propranolol. High concentrations caused contraction which was enhanced by propranolol but blocked by phenoxybenzamine.

4 Detrusor muscle was relaxed by isoprenaline and this effect was blocked by propranolol. Phenylephrine caused relaxation of detrusor which was unaffected by phenoxybenzamine; in some cases contraction was produced in the presence of propranolol.

5 It is concluded that the bladder neck contains mainly α-receptors and the detrusor mainly β-receptors but both regions posses both types of adrenoceptor.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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