Abstract
1 The rat stomach strip was used to assay prostaglandin E2-like material released by a rabbit isolated kidney perfused with Krebs solution.
2 Doses of noradrenaline and angiotensin II producing similar vasoconstrictor effects released equivalent amounts of prostaglandins from the kidney.
3 8-Leu-angiotensin II, a specific inhibitor of the natural octapeptide, blocked the action of angiotensin II on perfusion pressure and the release of prostaglandins, while the action of noradrenaline on both parameters was unaffected.
4 Indomethacin, a specific inhibitor of prostaglandin biosynthesis, blocked the effects of both vasoconstrictors on prostaglandin release while their action on perfusion pressure was significantly enhanced.
5 In the kidney effluent, amounts of prostaglandin E2-like material increased linearly with the rise in perfusion pressure induced by increasing doses of angiotensin II. These results indicate that prostaglandin output from the isolated kidney follows the rise in perfusion pressure.
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Selected References
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- Aiken J. W., Vane J. R. Intrarenal prostaglandin release attenuates the renal vasoconstrictor activity of angiotensin. J Pharmacol Exp Ther. 1973 Mar;184(3):678–687. [PubMed] [Google Scholar]
- Daniels E. G., Hinman J. W., Leach B. E., Muirhead E. E. Identification of prostaglandin E2 as the principal vasodepressor lipid of rabbit renal medulla. Nature. 1967 Sep 16;215(5107):1298–1299. doi: 10.1038/2151298a0. [DOI] [PubMed] [Google Scholar]
- Davis H. A., Horton E. W. Output of prostaglandins from the rabbit kidney, its increase on renal nerve stimulation and its inhibition by indomethacin. Br J Pharmacol. 1972 Dec;46(4):658–675. doi: 10.1111/j.1476-5381.1972.tb06891.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Douglas J. R., Jr, Johnson E. M., Jr, Marshall G. R., Jaffe B. M., Needleman P. Stimulation of splenic prostaglandin release by angiotensin and specific inhibition by cysteine 8-AII. Prostaglandins. 1973 Jan;3(1):67–74. doi: 10.1016/0090-6980(73)90138-x. [DOI] [PubMed] [Google Scholar]
- Dunham E. W., Zimmerman B. G. Release of prostaglandin-like material from dog kidney during nerve stimulation. Am J Physiol. 1970 Nov;219(5):1279–1285. doi: 10.1152/ajplegacy.1970.219.5.1279. [DOI] [PubMed] [Google Scholar]
- Ferreira S. H., Moncada S., Vane J. R. Indomethacin and aspirin abolish prostaglandin release from the spleen. Nat New Biol. 1971 Jun 23;231(25):237–239. doi: 10.1038/newbio231237a0. [DOI] [PubMed] [Google Scholar]
- GADDUM J. H. The technique of superfusion. Br J Pharmacol Chemother. 1953 Sep;8(3):321–326. doi: 10.1111/j.1476-5381.1953.tb00801.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Higgs G. A., Youlten L. J. Proceedings: Prostaglandin production by rabbit peritoneal polymorphonuclear leukocytes in vitro. Br J Pharmacol. 1972 Feb;44(2):330P–330P. [PMC free article] [PubMed] [Google Scholar]
- McGiff J. C., Crowshaw K., Terragno N. A., Lonigro A. J. Release of a prostaglandin-like substance into renal venous blood in response to angiotensin II. Circ Res. 1970 Jul;27(1 Suppl 1):121–130. [PubMed] [Google Scholar]
- McGiff J. C., Crowshaw K., Terragno N. A., Malik K. U., Lonigro A. J. Differential effect of noradrenaline and renal nerve stimulation on vascular resistance in the dog kidney and the release of a prostaglandin E-like substance. Clin Sci. 1972 Feb;42(2):223–233. doi: 10.1042/cs0420223. [DOI] [PubMed] [Google Scholar]
- Regoli D., Gauthier R. Site of action of angiotensin and other vasoconstrictors on the kidney. Can J Physiol Pharmacol. 1971 Jun;49(6):608–612. doi: 10.1139/y71-078. [DOI] [PubMed] [Google Scholar]
- Regoli D., Park W. K., Rioux F., Chan C. S. Antagonists of angiotensin. Substitution of an aliphatic chain to phenyl ring in position 8. Rev Can Biol. 1971 Dec;30(4):319–329. [PubMed] [Google Scholar]
- VANE J. R. A sensitive method for the assay of 5-hydroxytryptamine. Br J Pharmacol Chemother. 1957 Sep;12(3):344–349. doi: 10.1111/j.1476-5381.1957.tb00146.x. [DOI] [PMC free article] [PubMed] [Google Scholar]