Abstract
Some of the effects of dipyridamole, hexobendine and lidoflazine on mechanical responses in rabbit duodenum have been investigated. In concentrations known to inhibit tissue accumulation of adenosine and its metabolites, none of these agents potentiated inhibitory responses to intramural nerve stimulation or to application of adenosine, adenosine triphosphate or phenylephrine. These results neither support nor dispute the suggestion that adenosine or a related nucleotide is the intramural inhibitory transmitter but do show that tissue accumulation in rabbit duodenum is not an important feature in the termination of the action of adenosine.
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Selected References
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- Burnstock G., Campbell G., Satchell D., Smythe A. Evidence that adenosine triphosphate or a related nucleotide is the transmitter substance released by non-adrenergic inhibitory nerves in the gut. Br J Pharmacol. 1970 Dec;40(4):668–688. doi: 10.1111/j.1476-5381.1970.tb10646.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Burnstock G. Purinergic nerves. Pharmacol Rev. 1972 Sep;24(3):509–581. [PubMed] [Google Scholar]
- De Potter W. P. Noradrenaline storage particles in splenic nerve. Philos Trans R Soc Lond B Biol Sci. 1971 Jun 17;261(839):313–317. doi: 10.1098/rstb.1971.0062. [DOI] [PubMed] [Google Scholar]
- Furness J. B., Costa M. The nervous release and the action of substances which affect intestinal muscle through neither adrenoreceptors nor cholinoreceptors. Philos Trans R Soc Lond B Biol Sci. 1973 Mar 15;265(867):123–133. doi: 10.1098/rstb.1973.0015. [DOI] [PubMed] [Google Scholar]
- Hulme M. E., Weston A. H. The accumulation of adenosine in rabbit intestinal muscle. Br J Pharmacol. 1974 Apr;50(4):569–574. doi: 10.1111/j.1476-5381.1974.tb08590.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Satchell D. G., Lynch A., Bourke P. M., Burnstock G. Potentiation of the effects of exogenously applied ATP and purinergic nerve stimulation on the guinea-pig taenia coli by dipyridamole and hexobendine. Eur J Pharmacol. 1972 Sep;19(3):343–350. doi: 10.1016/0014-2999(72)90100-8. [DOI] [PubMed] [Google Scholar]
- Stafford A. Potentiation of adenosine and the adenine nucleotides by dipyridamole. Br J Pharmacol Chemother. 1966 Nov;28(2):218–227. doi: 10.1111/j.1476-5381.1966.tb01888.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Su C., Bevan J. A., Burnstock G. [3H]adenosine triphosphate: release during stimulation of enteric nerves. Science. 1971 Jul 23;173(3994):336–338. doi: 10.1126/science.173.3994.336. [DOI] [PubMed] [Google Scholar]
- Weston A. H. Nerve-mediated inhibition of mechanical activity in rabbit duodenum and the effects of desensitization to adenosine and several of its derivatives. Br J Pharmacol. 1973 Jun;48(2):302–308. doi: 10.1111/j.1476-5381.1973.tb06916.x. [DOI] [PMC free article] [PubMed] [Google Scholar]