Abstract
1 Effects of graded doses of propranolol have been studied on gastric secretion and gastric ulcers in pylorus-ligated rats.
2 A dose-dependent action of propranolol was observed; small doses increased total volume, acid output and pepsin secretion along with an increase in the incidence of ulcers but high doses were inhibitory.
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Selected References
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- Bass P., Patterson M. A. Gastric secretory responses to drugs affecting adrenergic mechanisms in rats. J Pharmacol Exp Ther. 1967 Apr;156(1):142–149. [PubMed] [Google Scholar]
- Danhof I. E., Geumei A. Effect of propranolol on gastric acid secretion in rats. Br J Pharmacol. 1972 Sep;46(1):170–171. doi: 10.1111/j.1476-5381.1972.tb06860.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Djahanguiri B., Sadeghi D., Hemmati S. Système orthosympathique et ulcères gastriques exppeimentaux. Arch Int Pharmacodyn Ther. 1968 May;173(1):154–161. [PubMed] [Google Scholar]
- Djahanguiri B., Sadeghi D., Pousti A., Hemmati S., Firouzabadi A. Effect of a single dose of phentolamine, MJ 1999 and isoproterenol on histmaine-induced gastric ulcer in guinea pigs. Eur J Pharmacol. 1968 Feb;2(4):315–316. doi: 10.1016/0014-2999(68)90083-6. [DOI] [PubMed] [Google Scholar]
- Geumei A., Issa I., el-Gendi M., Abd-el-Samie Y. Inhibitory effect of beta-adrenergic-blocking agent propranolol on histamine-stimulated gastric acid secretion in man. Am J Dig Dis. 1972 Jan;17(1):55–58. doi: 10.1007/BF02239261. [DOI] [PubMed] [Google Scholar]
- Konturek S. J., Oleksy J. The effect of cholinergic and adrenergic blockage on basal and pentagastrin-induced acid secretion. Scand J Gastroenterol. 1969;4(1):13–16. doi: 10.3109/00365526909180145. [DOI] [PubMed] [Google Scholar]
- LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
- Misher A., Pendleton R. G., Staples R. Effects of adrenergic drugs upon gastric secretion in rats. Gastroenterology. 1969 Sep;57(3):294–299. [PubMed] [Google Scholar]
- Okabe S., Saziki R., Takagi K. Effects of adrenergic blocking agents on gastric secretion and stress-induced gastric ulcer in rats. Jpn J Pharmacol. 1970 Mar;20(1):10–15. doi: 10.1254/jjp.20.10. [DOI] [PubMed] [Google Scholar]
- Pradhan S. N., Wingate H. W. Effects of some adrenergic blocking agents on gastric secretion in dogs. Arch Int Pharmacodyn Ther. 1966 Aug;162(2):303–310. [PubMed] [Google Scholar]
- Takagi K., Okabe S., Yano S., Kawashima K., Saziki R. The effect of propranolol on the stress and Shay ulcerations in rats. Jpn J Pharmacol. 1969 Jun;19(2):327–329. doi: 10.1254/jjp.19.327. [DOI] [PubMed] [Google Scholar]