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. 1974 Jun;51(2):207–212. doi: 10.1111/j.1476-5381.1974.tb09648.x

The effects of intraventricular 6-hydroxydopamine on body temperature and arterial blood pressure in cats and rabbits

PJ Lewis, MD Rawlins, JL Reid
PMCID: PMC1776746  PMID: 4451740

Abstract

1 In unanaesthetized cats, the administration of 6-hydroxydopamine (6-OHDA), 750 μg, via the lateral cerebral ventricle produced a pronounced fall in rectal temperature but only a slight fall when repeated 7 days later. At this time hypothalamic noradrenaline concentration had diminished to 4% of control.

2 In these animals, the hypothermic response to exogenous noradrenaline, 100 μg, given via the same route was uninfluenced by pretreatment with 6-OHDA.

3 In unanaesthetized rabbits, intraventricular noradrenaline, 100 μg, produced a rise in rectal temperature and a biphasic effect on arterial pressure, a rise lasting 30 min followed by a fall.

4 Intraventricular 6-OHDA, 750 μg, in unanaesthetized rabbits produced a rise in body temperature and a rise in arterial pressure. The same dose given to rabbits depleted of central noradrenaline with central 6-OHDA produced rises in body temperature and arterial pressure of similar magnitude, but of slower onset.

5 These results suggest that intraventricular 6-OHDA releases noradrenaline from central neurones and that these neurones subserve thermoregulatory functions in both species. In the rabbit, central noradrenergic neurones can raise arterial pressure.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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