Abstract
Intracellular chloride activities have been measured in muscle fibres with chloride-sensitive electrodes. It was found that the depolarization induced by carbachol produces an influx of chloride ions, the accumulation of which leads to further sustained depolarization. The present study thus confirms the evidence put forward by Jenkinson & Terrar (1973) of an influence of chloride ions on the membrane potential after a prolonged application of carbachol.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Adrian R. H., Freygang W. H. The potassium and chloride conductance of frog muscle membrane. J Physiol. 1962 Aug;163(1):61–103. doi: 10.1113/jphysiol.1962.sp006959. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HODGKIN A. L., HOROWICZ P. The influence of potassium and chloride ions on the membrane potential of single muscle fibres. J Physiol. 1959 Oct;148:127–160. doi: 10.1113/jphysiol.1959.sp006278. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hutter O. F., Warner A. E. The pH sensitivity of the chloride conductance of frog skeletal muscle. J Physiol. 1967 Apr;189(3):403–425. doi: 10.1113/jphysiol.1967.sp008176. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hutter O. F., Warner A. E. The voltage dependence of the chloride conductance of frog muscle. J Physiol. 1972 Dec;227(1):275–290. doi: 10.1113/jphysiol.1972.sp010032. [DOI] [PMC free article] [PubMed] [Google Scholar]
- JENKINSON D. H., NICHOLLS J. G. Contractures and permeability changes produced by acetylcholine in depolarized denervated muscle. J Physiol. 1961 Nov;159:111–127. doi: 10.1113/jphysiol.1961.sp006796. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jenkinson D. H., Terrar D. A. Influence of chloride ions on changes in membrane potential during prolonged application of carbachol to frog skeletal muscle. Br J Pharmacol. 1973 Feb;47(2):363–376. doi: 10.1111/j.1476-5381.1973.tb08334.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- TAKEUCHI A., TAKEUCHI N. On the permeability of end-plate membrane during the action of transmitter. J Physiol. 1960 Nov;154:52–67. doi: 10.1113/jphysiol.1960.sp006564. [DOI] [PMC free article] [PubMed] [Google Scholar]