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. 1974 Jun;51(2):217–223. doi: 10.1111/j.1476-5381.1974.tb09650.x

Can the actions of adrenoceptor agonists and antagonists on pentagastrin-induced gastric secretion be due to their effects on histamine formation?

BP Curwain, Pamela Holton, RL McIsaac, Jan Spencer
PMCID: PMC1776751  PMID: 4451742

Abstract

1 The effects of some adrenoceptor agonists and antagonists which have been reported to affect histamine formation in leucocytes (Assem & Feigenbaum, 1972) have been investigated on gastric secretion in conscious dogs with Heidenhain pouches.

2 Submaximal secretion in response to pentagastrin was enhanced by propranolol (0.1-1.0 mg/kg i.v.) and phenylephrine (1.0 μg kg-1 min-1 i.v. for 20 min), which increase histamine formation, and was decreased by phentolamine (2 mg/kg i.v.) and isoprenaline (0.05-0.2 μg kg-1 min-1 i.v. for 30 min), which decrease histamine formation. Practolol (2 mg/kg i.v.), which has no effect on histamine formation, had no effect on secretion.

3 Acid secretion in response to histamine was either unaffected or affected in the opposite direction by these drugs.

4 The effects of the drugs on pentagastrin-induced secretion were not secondary to changes in mucosal blood flow (radioactive aniline clearance).

5 The results are consistent with the hypothesis that acid secretion in response to pentagastrin involves the formation of endogenous histamine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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