Abstract
The α- and β-adrenoceptor activities of the isolated rat uterus during the oestrous cycle were intluenced greatly by temperature changes. During dioestrus, lowering the bath temperature to 25°C from 40°C increased two-fold the inhibition produced by (-)-adrenaline, (-)-noradrenaline, (-)-phenylephrine and (-)-isoprenaline. During oestrus adrenaline, noradrenaline and phenylephrine produced biphasic responses of contraction followed by inhibition at 40°C and isoprenaline produced only inhibition. At 25°C the contractile α-responses either were abolished (phenylephrine) or greatly reduced (adrenaline and noradrenaline), while the inhibitory β-effects of all four amines were increased.
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Selected References
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- Aiken J. W. Aspirin and indomethacin prolong parturition in rats: evidence that prostaglandins contribute to expulsion of fetus. Nature. 1972 Nov 3;240(5375):21–25. doi: 10.1038/240021a0. [DOI] [PubMed] [Google Scholar]
- Butterworth K. R., Randall M. J. The effects of alpha- and beta-adrenoceptor blocking agents on the responses of the rat uterus to catecholamines throughout the oestrus cycle. Br J Pharmacol. 1970 Sep;40(1):160P–161P. [PMC free article] [PubMed] [Google Scholar]
- Iversen L. L. Catecholamine uptake processes. Br Med Bull. 1973 May;29(2):130–135. doi: 10.1093/oxfordjournals.bmb.a070982. [DOI] [PubMed] [Google Scholar]
- LEVY B., TOZZI S. THE ADRENERGIC RECEPTIVE MECHANISM OF THE RAT UTERUS. J Pharmacol Exp Ther. 1963 Nov;142:178–184. [PubMed] [Google Scholar]
- RUDZIK A. D., MILLER J. W. The mechanism of uterine inhibitory action of relaxin-containing ovarian extracts. J Pharmacol Exp Ther. 1962 Oct;138:82–87. [PubMed] [Google Scholar]
- Tothill A. Investigation of adrenaline reversal in the rat uterus by the induction of resistance to isoprenaline. Br J Pharmacol Chemother. 1967 Mar;29(3):291–301. doi: 10.1111/j.1476-5381.1967.tb01960.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tothill A., Rathbone L., Willman E. Relation between prostaglandin E2 and adrenaline reversal in the rat uterus. Nature. 1971 Sep 3;233(5314):56–57. doi: 10.1038/233056a0. [DOI] [PubMed] [Google Scholar]
- Vane J. R., Williams K. I. The contribution of prostaglandin production to contractions of the isolated uterus of the rat. Br J Pharmacol. 1973 Aug;48(4):629–639. doi: 10.1111/j.1476-5381.1973.tb08250.x. [DOI] [PMC free article] [PubMed] [Google Scholar]