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. 1974 Jul;51(3):435–439. doi: 10.1111/j.1476-5381.1974.tb10679.x

Specific supersensitivity of smooth muscle to angiotensin II after nephrectomy

P Meyer, A Papadimitriou, M Worcel
PMCID: PMC1776789  PMID: 4375528

Abstract

1 The dose-response curves for angiotensin, 5-hydroxytryptamine and carbachol were obtained on rat uterus and colon excised 24 h after a bilateral nephrectomy or a sham operation.

2 There was a shift to the left in the dose-response curves to angiotensin of organs from nephrectomized animals. Dose-response curves to 5-hydroxytryptamine and carbachol were not affected by nephrectomy.

3 The interaction of the two competitive antagonists (1-Asn, 5-Ileu, 8-Ala)-angiotensin II and (1-Asn, 5-Ileu, 8-Ileu)-angiotensin II with angiotensin II receptors was tested in control and nephrectomized organs. There was a decrease of the KI values in colon muscle after nephrectomy.

4 In conclusion, nephrectomy produces a specific supersensitivity to angiotensin that seems to be due to a change in the structure of angiotensin receptors, at least in colon smooth muscle. This increase in sensitivity may be the result of the elimination of a tropic factor that acts on angiotensin receptor sites.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. JENKINSON D. H. The antagonism between tubocurarine and substances which depolarize the motor end-plate. J Physiol. 1960 Jul;152:309–324. doi: 10.1113/jphysiol.1960.sp006489. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. MILEDI R. Properties of regenerating neuromuscular synapses in the frog. J Physiol. 1960 Nov;154:190–205. doi: 10.1113/jphysiol.1960.sp006573. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. MILEDI R. The acetylcholine sensitivity of frog muscle fibres after complete or partial devervation. J Physiol. 1960 Apr;151:1–23. [PMC free article] [PubMed] [Google Scholar]
  4. NICKERSON M. Receptor occupancy and tissue response. Nature. 1956 Sep 29;178(4535):697–698. doi: 10.1038/178697b0. [DOI] [PubMed] [Google Scholar]
  5. Papadimitriou A., Worcel M. Dose-response curves for angiotensin II and synthetic analogues in three types of smooth muscle: existence of different forms of receptor sites for angiotensin II. Br J Pharmacol. 1974 Feb;50(2):291–297. doi: 10.1111/j.1476-5381.1974.tb08575.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. SCHILD H. O. Drug antagonism and pAx. Pharmacol Rev. 1957 Jun;9(2):242–246. [PubMed] [Google Scholar]
  7. STEPHENSON R. P. A modification of receptor theory. Br J Pharmacol Chemother. 1956 Dec;11(4):379–393. doi: 10.1111/j.1476-5381.1956.tb00006.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Sayers G., Beall R. J. Isolated adrenal cortex cells: hypersensitivity to adrenocorticotropic hormone after hypophysectomy. Science. 1973 Mar 30;179(4080):1330–1331. doi: 10.1126/science.179.4080.1330. [DOI] [PubMed] [Google Scholar]
  9. Turker R. K., Yamamoto M. Y., Khairallah P. A., Bumpus F. M. Competative antagonism of 8-ala-angiotensin II to angiotensins I and II on isolated rabbit aorta and rat colon. Eur J Pharmacol. 1971;15(3):285–291. doi: 10.1016/0014-2999(71)90094-x. [DOI] [PubMed] [Google Scholar]
  10. Worcel M., Meyer P., D'Auriac G. A., Milliez P. Role of angiotensin in normal blood pressure regulation. Pflugers Arch. 1969;310(3):251–263. doi: 10.1007/BF00587213. [DOI] [PubMed] [Google Scholar]

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