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. 1974 Oct;52(2):213–218. doi: 10.1111/j.1476-5381.1974.tb09702.x

Effect of sympathomimetic amines on the histamine forming capacity of human leucocytes

ESK Assem
PMCID: PMC1776858  PMID: 4155990

Abstract

1 The effects of α- and β-adrenoceptor stimulants on the histamine-forming capacity (HFC) of human isolated leucocytes have been studied, in vitro.

2 It was confirmed that antigen significantly stimulates the HFC of human leucocytes.

3 β-Adrenoceptor stimulants, such as isoprenaline and salbutamol (10-6-10-3 M) significantly inhibited the HFC of human leucocytes in the presence and absence of antigen. At concentrations lower than 10-6 M, this effect was not observed. In general the degree of inhibition of HFC by β-adrenoceptor stimulants followed their potency as β-adrenoceptor stimulants.

4 α-Adrenoceptor stimulants significantly stimulated leucocyte HFC; noradrenaline within a limited concentration of 10-6 M, while stimulation was seen consistently with phenylephrine at concentrations of 10-7-10-4 M. Adrenaline, which stimulates both α- and β-adrenoceptors, produced small inhibition, no effect, or a degree of stimulation.

5 Phentolamine, an α-adrenoceptor blocking agent, produced an effect opposite to that of the α-adrenoceptor stimulants, i.e. a significant inhibition of the HFC of human isolated leucocytes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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