Abstract
The comparative effectiveness of propranolol and ICI 66082, in inhibiting the release of renin from the kidney resulting from renal nerve stimulation, has been studied in the cat. Over the dose range 0.17-0.68 × 10-5 mol/kg propranolol there was a dose-response relationship with the increase of plasma renin activity (PRA) achieved after 10 min stimulation. Over the dose range 0.75-1.69 × 10-5 mol/kg ICI 66082 also inhibited the release of renin caused by nerve stimulation, but was about five times less effective than propranolol. It would appear from these data that the β-adrenoceptors within the kidney mediating renin release are distinctly different from those of the heart.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Aberg H. Plasma renin activity after the use of a new beta-adrenergic blocking agent (I.C.I. 66,032). Int J Clin Pharmacol. 1974 Mar;9(2):98–100. [PubMed] [Google Scholar]
- Assaykeen T. A., Clayton P. L., Goldfien A., Ganong W. F. The effect of alpha- and beta-adrenergic blocking agents on the renin response to hypoglycemia and epinephrine in dogs. Endocrinology. 1970 Dec;87(6):1318–1322. doi: 10.1210/endo-87-6-1318. [DOI] [PubMed] [Google Scholar]
- Barrett A. M., Carter J., Fitzgerald J. D., Hull R., Le Count D. A new type of cardioselective adrenoceptive blocking drug. Br J Pharmacol. 1973 Jun;48(2):340P–340P. [PMC free article] [PubMed] [Google Scholar]
- Coote J. H., Johns E. J., Macleod V. H., Singer B. Effect of renal nerve stimulation, renal blood flow and adrenergic blockade on plasma renin activity in the cat. J Physiol. 1972 Oct;226(1):15–36. doi: 10.1113/jphysiol.1972.sp009971. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Esler M. D., Nestel P. J. Evaluation of practolol in hypertension. Effects on sympathetic nervous system and renin responsiveness. Br Heart J. 1973 May;35(5):469–474. doi: 10.1136/hrt.35.5.469. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Johns E. J., Singer B. Effect of propranolol and theophylline on renin release caused by furosemide in the cat. Eur J Pharmacol. 1973 Jul;23(1):67–73. doi: 10.1016/0014-2999(73)90245-8. [DOI] [PubMed] [Google Scholar]
- Loeffler J. R., Stockigt J. R., Ganong W. F. Effect of alpha- and beta-adrenergic blocking agents on the increase in renin secretion produced by stimulation of the renal nerves. Neuroendocrinology. 1972;10(3):129–138. doi: 10.1159/000122112. [DOI] [PubMed] [Google Scholar]
- Meurer K. A. Die Bedeutung des sympathico-adrenalen Systems für die Reninfreisetzung. Klin Wochenschr. 1971 Sep 15;49(18):1001–1014. doi: 10.1007/BF01487731. [DOI] [PubMed] [Google Scholar]
- Passo S. S., Assaykeen T. A., Goldfien A., Ganong W. F. Effect of alpha- and beta-adrenergic blocking agents on the increase in renin secretion produced by stimulation of the medulla oblongata in dogs. Neuroendocrinology. 1971;7(2):97–104. doi: 10.1159/000121957. [DOI] [PubMed] [Google Scholar]
- Reid I. A., Schrier R. W., Earley L. E. An effect of extrarenal beta adrenergic stimulation on the release of renin. J Clin Invest. 1972 Jul;51(7):1861–1869. doi: 10.1172/JCI106988. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tobert J. A., Slater J. D., Fogelman F., Lightman S. L., Kurtz A. B., Payne N. N. The effect in man of (+)-propranolol and racemic propranolol on renin secretion stimulated by orthostatic stress. Clin Sci. 1973 Mar;44(3):291–295. doi: 10.1042/cs0440291. [DOI] [PubMed] [Google Scholar]
- Vander A. J. Effect of catecholamines and the renal nerves on renin secretion in anesthetized dogs. Am J Physiol. 1965 Sep;209(3):659–662. doi: 10.1152/ajplegacy.1965.209.3.659. [DOI] [PubMed] [Google Scholar]
- Vandongen R., Peart W. S., Boyd G. W. Andrenergic stimulation of renin secretion in the isolated perfused rat kidney. Circ Res. 1973 Feb;32(2):290–296. doi: 10.1161/01.res.32.2.290. [DOI] [PubMed] [Google Scholar]