Abstract
1 Cellulose sulphate (1 mg/kg) produced a 30-40% depletion of plasma kininogen in rats.
2 The time course of repletion of kininogen in the plasma was compared in rats in the oestrous and dioestrous stages of the cycle and in 22 day pregnant animals. A partial repletion occurred, 3 h after the cellulose sulphate injection, which was followed by a secondary fall in plasma kininogen. Plasma kininogen values were back to control levels 10 h after the treatment in all groups.
3 Treatment of rats from days 19-22 of pregnancy with cellulose sulphate resulted in 40% depletion of plasma kininogen and in prolongation of pre-parturition behaviour.
4 It is suggested that the increase which normally occurs in plasma kininogen levels towards the end of pregnancy in the rat may play a role in the process of parturition.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- DINIZ C. R., CARVALHO I. F. A micromethod for determination of bradykininogen under several conditions. Ann N Y Acad Sci. 1963 Feb 4;104:77–89. doi: 10.1111/j.1749-6632.1963.tb17654.x. [DOI] [PubMed] [Google Scholar]
- McCormick J. T., Senior J. Effect of sex hormones on the concentrations of plasma kininogen in the female rat. Br J Pharmacol. 1971 Oct;43(2):421P–422P. [PMC free article] [PubMed] [Google Scholar]
- McCormick J. T., Senior J. Plasma kinin and kininogen levels in the female rat during the oestrous cycle, pregnancy, parturition and the puerperium. Br J Pharmacol. 1974 Feb;50(2):237–241. doi: 10.1111/j.1476-5381.1974.tb08567.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McCormick J. T., Senior J. The effect of the oestrous cycle, pregnancy and reproductive hormones on the kininase activity of rat blood. J Reprod Fertil. 1972 Sep;30(3):381–387. doi: 10.1530/jrf.0.0300381. [DOI] [PubMed] [Google Scholar]
- Rosa A. T., Rothschild A. M., Rothschild Z. Fibrinolytic activity evoked in the plasma of the normal and adrenalectomized rat by cellulose sulphate. Br J Pharmacol. 1972 Jul;45(3):470–475. doi: 10.1111/j.1476-5381.1972.tb08103.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rothschild A. M. Some pharmacodynamic properties of cellulose sulphate, a kininogen-depleting agent in the rat. Br J Pharmacol Chemother. 1968 Jul;33(3):501–512. doi: 10.1111/j.1476-5381.1968.tb00498.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wiegerhausen B., Klausch B., Hennighausen G., Sosat R. Der Kininogenspiegel von Ratten und Kaninchen während der Gestation. Experientia. 1968 Nov 15;24(11):1128–1129. doi: 10.1007/BF02147802. [DOI] [PubMed] [Google Scholar]