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. 1974 Sep;52(1):93–96. doi: 10.1111/j.1476-5381.1974.tb09691.x

Antagonism of the effect of isoprenaline on heart rate by pilocarpine

C Sadavongvivad, Jutamaad Satayavivad
PMCID: PMC1776946  PMID: 4451811

Abstract

1 The interaction of pilocarpine and isoprenaline on heart rate was investigated in the spontaneously beating, right isolated atrium of the rat.

2 The log dose-effect curve of isoprenaline, measured in the presence of various concentrations of pilocarpine, was not modified when the concentration of the latter did not exceed 10-6 M even though significant slowing of the heart had occurred. At concentrations higher than 10-6 M a rapid but graded shift to the right of isoprenaline response curves occurred so that at pilocarpine 10-5 M the pD2 of isoprenaline was reduced from 11 to 3.3; cocaine slightly reduced this antagonism.

3 It is concluded that pilocarpine antagonizes isoprenaline by some mechanism which is not of the simple competitive type.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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