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. 1974 Sep;52(1):104–106. doi: 10.1111/j.1476-5381.1974.tb09694.x

Stimulation of rat gastric adenylate cyclase by histamine and histamine analogues and blockade by burimamide

JH McNeill, SC Verma
PMCID: PMC1776972  PMID: 4451768

Abstract

Histamine, 4-methylhistamine, 3-(β-aminoethyl)-1,2,4 triazole and betazole, in that order, stimulated adenylate cyclase prepared from rat gastric tissue in a dose-dependent manner. Burimamide, an H2-receptor blocking agent, in concentrations of 1-5 × 10-6 M antagonized this effect. The data lend some support to the hypothesis that elevated levels of cyclic adenosine 3',5'-monophosphate may be involved in histamine-stimulated gastric secretions and that H2-receptors are associated with adenylate cyclase.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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