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. 1974 Sep;52(1):69–75. doi: 10.1111/j.1476-5381.1974.tb09688.x

Implication of gastric mucosal histamine in inhibition by isoprenaline of pentagastrin-induced gastric secretion

L Lundell, SE Svensson
PMCID: PMC1776984  PMID: 4155986

Abstract

1 The effect of isoprenaline on pentagastrin-induced gastric secretion was studied in conscious rats with Heidenhain pouches. The influence of isoprenaline on pentagastrin-induced release and formation of gastric mucosal histamine was also examined.

2 Isoprenaline strongly inhibited pentagastrin-induced acid secretion, an inhibition which could not be overcome by increasing the dose of pentagastrin.

3 Propranolol blocked the inhibitory effect of isoprenaline on pentagastrin-induced acid secretion.

4 Isoprenaline enhanced pepsin secretion induced by pentagastrin, an effect which was blocked by propranolol.

5 Isoprenaline reduced the increase in formation and release of gastric mucosal histamine following pentagastrin infusion, an inhibitory influence which was almost completely blocked by propranolol.

6 The inhibition by isoprenaline of pentagastrin-induced acid secretion is tentatively related to alterations in gastric mucosal histamine occurring simultaneously.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALPHIN R. S., LIN T. M. Preparation of chronic denervated gastric pouches in the rat. Am J Physiol. 1959 Aug;197:257–259. doi: 10.1152/ajplegacy.1959.197.2.257. [DOI] [PubMed] [Google Scholar]
  2. Assem E. S., Feigenbaum J. J. Effect of adrenergic drugs on histamine forming capacity of human leucocytes. Br J Pharmacol. 1972 Nov;46(3):519P–520P. doi: 10.1111/j.1476-5381.1972.tb08152.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Assem E. S., Schild H. O. Antagonism by beta-adrenoceptor blocking agents of the antianaphylactic effect of isoprenaline. Br J Pharmacol. 1971 Aug;42(4):620–630. doi: 10.1111/j.1476-5381.1971.tb07146.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Assem E. S., Schild H. O. Inhibition by sympathomimetic amines of histamine release by antigen in passively sensitized human lung. Nature. 1969 Dec 6;224(5223):1028–1029. doi: 10.1038/2241028a0. [DOI] [PubMed] [Google Scholar]
  5. Bass P., Patterson M. A. Gastric secretory responses to drugs affecting adrenergic mechanisms in rats. J Pharmacol Exp Ther. 1967 Apr;156(1):142–149. [PubMed] [Google Scholar]
  6. Bitsch V. A modification of the Hunt method for estimating peptic activity in gastric juice. Scand J Clin Lab Invest. 1966;18(3):357–358. doi: 10.3109/00365516609087209. [DOI] [PubMed] [Google Scholar]
  7. Curwain B. P., Holton P., Spencer J. Enhancement by propranolol of gastric acid secretion in response to pentagastrin in conscious dogs. Br J Pharmacol. 1973 Jun;48(2):341P–342P. [PMC free article] [PubMed] [Google Scholar]
  8. Curwain B. P., Holton P. The effects of isoprenaline and noradrenaline on pentagastrin-stimulated gastric acid secretion and mucosal blood flow in the dog. Br J Pharmacol. 1972 Oct;46(2):225–233. doi: 10.1111/j.1476-5381.1972.tb06867.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. FELDBERG W., TALESNIK J. Reduction of tissue histamine by compound 48/80. J Physiol. 1953 Jun 29;120(4):550–568. doi: 10.1113/jphysiol.1953.sp004917. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Faulkner S. L., Hopkins J. T., Boerth R. C., Young J. L., Jr, Jellett L. V., Nies A. S., Bender H. W., Shand D. G. Time required for complete recovery from chronic propranolol therapy. N Engl J Med. 1973 Sep 20;289(12):607–609. doi: 10.1056/NEJM197309202891204. [DOI] [PubMed] [Google Scholar]
  11. Fletcher T. L., Pitts C. L., Everett M. T., Griffith C. A. Effect of 4-bromo-3-hydroxybenzyloxyamine (Brocresine) on gastric secretion in pouch dogs. Proc Soc Exp Biol Med. 1969 Oct;132(1):205–211. doi: 10.3181/00379727-132-34181. [DOI] [PubMed] [Google Scholar]
  12. GRAHAM P., KAHLSON G., ROSENGREN E. HISTAMINE FORMATION IN PHYSICAL EXERCISE, ANOXIA AND UNDER THE INFLUENCE OF ADRENALINE AND RELATED SUBSTANCES. J Physiol. 1964 Aug;172:174–188. doi: 10.1113/jphysiol.1964.sp007411. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Hayes J. R., Kennedy T. L., Ardill J., Shanks R. G., Buchanan K. D. Stimulation of gastrin release by catecholamines. Lancet. 1972 Apr 15;1(7755):819–821. doi: 10.1016/s0140-6736(72)90802-1. [DOI] [PubMed] [Google Scholar]
  14. Henman F. D. Gastric effects of cycloheximide. Gut. 1972 Apr;13(4):323–324. [PubMed] [Google Scholar]
  15. Johansson I., Lundell L., Rosengren E., Svensson S. E. Gastric secretion and its facilitation as related to gastric mucosal histamine. J Physiol. 1972 Oct;226(2):431–452. doi: 10.1113/jphysiol.1972.sp009992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Konturek S. J., Oleksy J. The effect of cholinergic and adrenergic blockage on basal and pentagastrin-induced acid secretion. Scand J Gastroenterol. 1969;4(1):13–16. doi: 10.3109/00365526909180145. [DOI] [PubMed] [Google Scholar]
  17. Levine R. J. Effect of histidine decarboxylase inhibition on gastric acid secretion in the rat. Fed Proc. 1965 Nov-Dec;24(6):1331–1333. [PubMed] [Google Scholar]
  18. Lin T. M., Evans D. C. Effect of propranolol on pentagastrin-induced HC1 secretion and gastric mucosal blood flow in dogs. Gastroenterology. 1973 Jun;64(6):1126–1129. [PubMed] [Google Scholar]
  19. Misher A., Pendleton R. G., Staples R. Effects of adrenergic drugs upon gastric secretion in rats. Gastroenterology. 1969 Sep;57(3):294–299. [PubMed] [Google Scholar]
  20. SCHAYER R. W., DAVIS K. J., SMILEY R. L. Binding of histamine in vitro and its inhibition by cortisone. Am J Physiol. 1955 Jul;182(1):54–56. doi: 10.1152/ajplegacy.1955.182.1.54. [DOI] [PubMed] [Google Scholar]
  21. Snyder S. H., Epps L. Regulation of histidine decarboxylase in rat stomach by gastrin: the effect of inhibitors of protein synthesis. Mol Pharmacol. 1968 Mar;4(2):187–195. [PubMed] [Google Scholar]
  22. Stadil F., Rehfeld J. F. Release of gastrin by epinephrine in man. Gastroenterology. 1973 Aug;65(2):210–215. [PubMed] [Google Scholar]
  23. Svensson S. E. The secretory pattern of three stomach preparations in the rat. J Physiol. 1970 Apr;207(2):329–350. doi: 10.1113/jphysiol.1970.sp009064. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Thayer W. R., Jr, Martin H. F. Histidine decarboxylase inhibition and gastric secretion. Am J Dig Dis. 1967 Oct;12(10):1050–1061. doi: 10.1007/BF02233265. [DOI] [PubMed] [Google Scholar]
  25. Yeh S. D., Shils M. E. Cycloheximide inhibition of gastric secretion in the rat. Proc Soc Exp Biol Med. 1969 Mar;130(3):807–810. doi: 10.3181/00379727-130-33660. [DOI] [PubMed] [Google Scholar]

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