Abstract
Rectal suppositories as an alternative to intravenous aminophylline in the management of recurrent apnoea were studied in 41 preterm infants of mean gestation 28.3 weeks and mean birthweight 1176 g. Therapeutic blood concentrations were obtained two hours after a rectal loading dose of 10 mg/kg, with steady concentrations and maximum reduction in apnoeic episodes (from a mean of 0.5 per hour to 0.09 per hour) within 24 hours on a maintenance dose of 10 mg/kg/day. There was good correlation between the rectal dose and the plasma theophylline concentration. Several infants showed a significant reduction in Pco2 when treated with aminophylline. Side effects were related to the plasma theophylline concentration and were not seen at concentrations less than 14 mg/l.
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Selected References
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- Aranda J. V., Sitar D. S., Parsons W. D., Loughnan P. M., Neims A. H. Pharmacokinetic aspects of theophylline in premature newborns. N Engl J Med. 1976 Aug 19;295(8):413–416. doi: 10.1056/NEJM197608192950803. [DOI] [PubMed] [Google Scholar]
- Bednarek F. J., Roloff D. W. Treatment of apnea of prematurity with aminophylline. Pediatrics. 1976 Sep;58(3):335–339. [PubMed] [Google Scholar]
- Davi M. J., Sankaran K., Simons K. J., Simons F. E., Seshia M. M., Rigatto H. Physiologic changes induced by theophylline in the treatment of apnea in preterm infants. J Pediatr. 1978 Jan;92(1):91–95. doi: 10.1016/s0022-3476(78)80084-5. [DOI] [PubMed] [Google Scholar]
- Jones R. A., Baillie E. Dosage schedule for intravenous aminophylline in apnoea of prematurity, based on pharmacokinetic studies. Arch Dis Child. 1979 Mar;54(3):190–193. doi: 10.1136/adc.54.3.190. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kuzemko J. A., Paala J. Apnoeic attacks in the newborn treated with aminophylline. Arch Dis Child. 1973 May;48(5):404–406. doi: 10.1136/adc.48.5.404. [DOI] [PMC free article] [PubMed] [Google Scholar]
- NOLKE A. C. Severe toxic effects from aminophylline and theophylline suppositories in children. J Am Med Assoc. 1956 Jun 23;161(8):693–697. doi: 10.1001/jama.1956.02970080023008. [DOI] [PubMed] [Google Scholar]
- ROUNDS V. J. Aminophylline poisoning. Pediatrics. 1954 Nov;14(5):528–532. [PubMed] [Google Scholar]
- Shannon D. C., Gotay F., Stein I. M., Rogers M. C., Todres I. D., Moylan F. M. Prevention of apnea and bradycardia in low-birthweight infants. Pediatrics. 1975 May;55(5):589–594. [PubMed] [Google Scholar]