Abstract
Single oral dose trimethoprim pharmacokinetics were determined in 18 children aged 3 months to 13 years. Trimethoprim suspension was rapidly absorbed and quickly and widely distributed. The mean clearance was considerably faster and the elimination half life considerably shorter than values reported in adults. Only one third of the administered drug dose was recovered from the urine within 24 hours which is considerably less than in adults, suggesting that children may metabolise a greater proportion of the dose given. Urine trimethoprim concentrations greatly in excess of minimum inhibitory concentrations for common pathogens were rapidly achieved and sustained for at least 16 hours.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Kaplan S. A., Weinfeld R. E., Abruzzo C. W., McFaden K., Jack M. L., Weissman L. Pharmacokinetic profile of trimethoprim-sulfamethoxazole in man. J Infect Dis. 1973 Nov;128(Suppl):547–p. doi: 10.1093/infdis/128.supplement_3.s547. [DOI] [PubMed] [Google Scholar]
- Kasanen A., Anttila M., Elfving R., Kahela P., Saarimaa H., Sundquist H., Tikkanen R., Toivanen P. Trimethoprim. Pharmacology, antimicrobial activity and clinical use in urinary tract infections. Ann Clin Res. 1978;10 (Suppl 22):1–39. [PubMed] [Google Scholar]
- Kremers P., Biertho G., Chantraine J. M., Heusghem C. Etude pharmacocinétique de l'association sulfaméthoxazole-triméthoprime chez l'enfant. Therapie. 1973 Nov-Dec;28(6):1177–1184. [PubMed] [Google Scholar]
- Langlois Y., Gagnon M. A., Tétreault L. A bioavailability study on three oral preparations of the combination trimethoprim-sulfamethoxazole. J Clin Pharmacol New Drugs. 1972 May-Jun;12(5):196–200. doi: 10.1002/j.1552-4604.1972.tb00161.x. [DOI] [PubMed] [Google Scholar]
- Rane A., Wilson J. T. Clinical pharmacokinetics in infants and children. Clin Pharmacokinet. 1976;1(1):2–24. doi: 10.2165/00003088-197601010-00002. [DOI] [PubMed] [Google Scholar]
- Siber G. R., Gorham C. C., Ericson J. F., Smith A. L. Pharmacokinetics of intravenous trimethoprim-sulfamethoxazole in children and adults with normal and impaired renal function. Rev Infect Dis. 1982 Mar-Apr;4(2):566–578. doi: 10.1093/clinids/4.2.566. [DOI] [PubMed] [Google Scholar]
- Sigel C. W., Grace M. E., Nichol C. A. Metabolism of trimethoprim in man and measurement of a new metabolite: a new fluorescence assay. J Infect Dis. 1973 Nov;128(Suppl):580–p. doi: 10.1093/infdis/128.supplement_3.s580. [DOI] [PubMed] [Google Scholar]
- Watson I. D., Cohen H. N., Stewart M. J., McIntosh S. J., Shenkin A., Thomson J. A. Comparative pharmacokinetics of co-trifamole and co-trimoxazole to 'steady state' in normal subjects. Br J Clin Pharmacol. 1982 Sep;14(3):437–443. doi: 10.1111/j.1365-2125.1982.tb02004.x. [DOI] [PMC free article] [PubMed] [Google Scholar]