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. 1985 Feb;60(2):99–104. doi: 10.1136/adc.60.2.99

Haemoglobin concentration depends on protein intake in small preterm infants fed human milk.

K A Rönnholm, M A Siimes
PMCID: PMC1777153  PMID: 3977401

Abstract

Studies have shown that early anaemia of prematurity cannot be prevented by iron or vitamin supplementation. We studied 35 infants of birthweight less than 1520 g and mean gestational age 30.4 weeks who were fed either human milk alone or human milk supplemented with human milk protein. The vitamin and iron status were the same in both groups but the concentration of haemoglobin was significantly higher at the ages 4 to 10 weeks in the protein supplemented infants. Reticulocytosis occurred earlier in the protein supplemented infants. The findings on haemoglobin and reticulocytes were similar in 18 infants who received no blood transfusions. We conclude that human milk protein supplementation can increase the haemoglobin concentration of very low birthweight infants in the early weeks of life and that the protein content in human milk may be insufficient to satisfy their needs.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brown M. S., Phibbs R. H., Garcia J. F., Dallman P. R. Postnatal changes in erythropoietin levels in untransfused premature infants. J Pediatr. 1983 Oct;103(4):612–617. doi: 10.1016/s0022-3476(83)80600-3. [DOI] [PubMed] [Google Scholar]
  2. Chromy V., Fischer J. Photometric determination of total protein in lipemic sera. Clin Chem. 1977;23(4):754–756. [PubMed] [Google Scholar]
  3. Dallman P. R. Anemia of prematurity. Annu Rev Med. 1981;32:143–160. doi: 10.1146/annurev.me.32.020181.001043. [DOI] [PubMed] [Google Scholar]
  4. Evans G. W. Copper homeostasis in the mammalian system. Physiol Rev. 1973 Jul;53(3):535–570. doi: 10.1152/physrev.1973.53.3.535. [DOI] [PubMed] [Google Scholar]
  5. Hashim S. A., Schuttringer G. R. Rapid determination of tocopherol in marco- and microquantities of plasma. Results obtained in various nutrition and metabolic studies. Am J Clin Nutr. 1966 Aug;19(2):137–145. doi: 10.1093/ajcn/19.2.137. [DOI] [PubMed] [Google Scholar]
  6. Hågå P. Ceruloplasmin levels and erythrocyte superoxide dismutase activity in small preterm infants during the early anemia of prematurity. Acta Paediatr Scand. 1981 Nov;70(6):861–864. doi: 10.1111/j.1651-2227.1981.tb06240.x. [DOI] [PubMed] [Google Scholar]
  7. Kumar V., Chase P., Hammond K., O'Brien D. Alterations in blood biochemical tests in progressive protein malnutrition. Pediatrics. 1972 May;49(5):736–743. [PubMed] [Google Scholar]
  8. Oski F. A., Barness L. A. Vitamin E deficiency: a previously unrecognized cause of hemolytic anemia in the premature infant. J Pediatr. 1967 Feb;70(2):211–220. doi: 10.1016/s0022-3476(67)80416-5. [DOI] [PubMed] [Google Scholar]
  9. Rudolph N., Preis O., Bitzos E. I., Reale M. M., Wong S. L. Hematologic and selenium status of low-birth-weight infants fed formulas with and without iron. J Pediatr. 1981 Jul;99(1):57–62. doi: 10.1016/s0022-3476(81)80957-2. [DOI] [PubMed] [Google Scholar]
  10. Räihä N. C., Heinonen K., Rassin D. K., Gaull G. E. Milk protein quantity and quality in low-birthweight infants: I. Metabolic responses and effects on growth. Pediatrics. 1976 May;57(5):659–684. [PubMed] [Google Scholar]
  11. Rönnholm K. A., Sipilä I., Siimes M. A. Human milk protein supplementation for the prevention of hypoproteinemia without metabolic imbalance in breast milk-fed, very low-birth-weight infants. J Pediatr. 1982 Aug;101(2):243–247. doi: 10.1016/s0022-3476(82)80133-9. [DOI] [PubMed] [Google Scholar]
  12. Siimes M. A., Järvenpä A. L. Prevention of anemia and iron deficiency in very low-birth-weight infants. J Pediatr. 1982 Aug;101(2):277–280. doi: 10.1016/s0022-3476(82)80141-8. [DOI] [PubMed] [Google Scholar]
  13. Siimes M. A., Salmenperä L., Perheentupa J. Exclusive breast-feeding for 9 months: risk of iron deficiency. J Pediatr. 1984 Feb;104(2):196–199. doi: 10.1016/s0022-3476(84)80991-9. [DOI] [PubMed] [Google Scholar]
  14. Stockman J. A., 3rd, Oski F. A. Physiological anaemia of infancy and the anaemia of prematurity. Clin Haematol. 1978 Feb;7(1):3–18. [PubMed] [Google Scholar]
  15. Vertongen F., Heyder-Bruckner C., Fondu P., Mandelbaum I. Oxidative haemolysis in protein malnutrition. Clin Chim Acta. 1981 Oct 26;116(2):217–222. doi: 10.1016/0009-8981(81)90025-5. [DOI] [PubMed] [Google Scholar]
  16. Wardrop C. A., Holland B. M., Veale K. E., Jones J. G., Gray O. P. Nonphysiological anaemia of prematurity. Arch Dis Child. 1978 Nov;53(11):855–860. doi: 10.1136/adc.53.11.855. [DOI] [PMC free article] [PubMed] [Google Scholar]

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