Skip to main content
PMC home page
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1985 Apr;60(4):326–332. doi: 10.1136/adc.60.4.326

Intestinal permeability changes and excretion of micro-organisms in stools of infants with diarrhoea and vomiting.

L T Weaver, P D Chapman, C R Madeley, M F Laker, R Nelson
PMCID: PMC1777215  PMID: 3923945

Abstract

The relation between diarrhoea and vomiting, the excretion of stool micro-organisms, and the passive intestinal permeability in 20 infants living in a deprived urban area was studied prospectively from birth to age 6 months. Intestinal permeability was measured from the ratio of lactulose to mannitol recovered in the urine of infants receiving feeds containing both markers. Micro-organism excretion was found to occur in both the presence and absence of gastrointestinal symptoms, but a significantly higher mean intestinal permeability was recorded in those infants with symptoms and organisms in the stool than in those with neither. An increased intestinal permeability may be a sign of mucosal damage by intestinal micro-organisms.

Full text

PDF
326

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barnes G. L., Townley R. R. Duodenal mucosal damage in 31 infants with gastroenteritis. Arch Dis Child. 1973 May;48(5):343–349. doi: 10.1136/adc.48.5.343. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Beach R. C., Menzies I. S. Lactulose and other non-absorbable sugars in infant milk feeds. Lancet. 1983 Feb 19;1(8321):425–426. doi: 10.1016/s0140-6736(83)91548-9. [DOI] [PubMed] [Google Scholar]
  3. Bishop R. F., Davidson G. P., Holmes I. H., Ruck B. J. Virus particles in epithelial cells of duodenal mucosa from children with acute non-bacterial gastroenteritis. Lancet. 1973 Dec 8;2(7841):1281–1283. doi: 10.1016/s0140-6736(73)92867-5. [DOI] [PubMed] [Google Scholar]
  4. Buts J. P., Morin C. L., Roy C. C., Weber A., Bonin A. One-hour blood xylose test: a reliable index of small bowel function. J Pediatr. 1978 May;92(5):729–733. doi: 10.1016/s0022-3476(78)80138-3. [DOI] [PubMed] [Google Scholar]
  5. Challacombe D. N., Richardson J. M., Rowe B., Anderson C. M. Bacterial microflora of the upper gastrointestinal tract in infants with protracted diarrhoea. Arch Dis Child. 1974 Apr;49(4):270–277. doi: 10.1136/adc.49.4.270. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Christie D. L. Use of the one-hour blood xylose test as an indicator of small bowel mucosal disease. J Pediatr. 1978 May;92(5):725–728. doi: 10.1016/s0022-3476(78)80137-1. [DOI] [PubMed] [Google Scholar]
  7. Harrison M., Walker-Smith J. A. Reinvestigation of lactose intolerant children: lack of correlation between continuing lactose intolerance and small intestinal morphology, disaccharidase activity, and lactose tolerance tests. Gut. 1977 Jan;18(1):48–52. doi: 10.1136/gut.18.1.48. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Laker M. F., Bull H. J., Menzies I. S. Evaluation of mannitol for use as a probe marker of gastrointestinal permeability in man. Eur J Clin Invest. 1982 Dec;12(6):485–491. doi: 10.1111/j.1365-2362.1982.tb02230.x. [DOI] [PubMed] [Google Scholar]
  9. Laker M. F. Estimation of disaccharides in plasma and urine by gas-liquid chromatography. J Chromatogr. 1979 May 1;163(1):9–18. doi: 10.1016/s0378-4347(00)81163-9. [DOI] [PubMed] [Google Scholar]
  10. Laker M. F., Menzies I. S. Increase in human intestinal permeability following ingestion of hypertonic solutions. J Physiol. 1977 Mar;265(3):881–894. doi: 10.1113/jphysiol.1977.sp011750. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Madeley C. R., Cosgrove B. P., Bell E. J., Fallon R. J. Stool viruses in babies in Glasgow. I. Hospital admissions with diarrhoea. J Hyg (Lond) 1977 Apr;78(2):261–273. doi: 10.1017/s0022172400056151. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Mavromichalis J., Evans N., McNeish A. S., Bryden A. S., Davies H. A., Flewett T. H. Intestinal damage in rotavirus and adenovirus gastroenteritis assessed by d-xylose malabsorption. Arch Dis Child. 1977 Jul;52(7):589–591. doi: 10.1136/adc.52.7.589. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Pearson A. D., Craft A. W., Pledger J. V., Eastham E. J., Laker M. F., Pearson G. L. Small bowel function in acute lymphoblastic leukaemia. Arch Dis Child. 1984 May;59(5):460–465. doi: 10.1136/adc.59.5.460. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Pearson A. D., Eastham E. J., Laker M. F., Craft A. W., Nelson R. Intestinal permeability in children with Crohn's disease and coeliac disease. Br Med J (Clin Res Ed) 1982 Jul 3;285(6334):20–21. doi: 10.1136/bmj.285.6334.20. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Scott T. M., Madeley C. R., Cosgrove B. P., Stanfield J. P. Stool viruses in babies in Glasgow. 3. Community studies. J Hyg (Lond) 1979 Dec;83(3):469–485. doi: 10.1017/s0022172400026310. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Walther F. J., Bruggeman C., Daniëls-Bosman M. S., Pourier S., Grauls G., Stals F., Bogaard A. V. Symptomatic and asymptomatic rotavirus infections in hospitalized children. Acta Paediatr Scand. 1983 Sep;72(5):659–663. doi: 10.1111/j.1651-2227.1983.tb09790.x. [DOI] [PubMed] [Google Scholar]
  17. Weaver L. T., Laker M. F., Nelson R. Enhanced intestinal permeability in preterm babies with bloody stools. Arch Dis Child. 1984 Mar;59(3):280–281. doi: 10.1136/adc.59.3.280. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Weaver L. T., Laker M. F., Nelson R. Intestinal permeability in the newborn. Arch Dis Child. 1984 Mar;59(3):236–241. doi: 10.1136/adc.59.3.236. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES