Abstract
Fifty two preschool children with asthma were given a recommended regimen of slow release theophylline. There was wide variation in the metabolism of theophylline. The approach adopted gave disappointing results. Nine children did not comply, and 16 stopped treatment because of side effects. Of the remainder, control of asthma was poor in 15 and satisfactory in 12.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ellis E. F., Koysooko R., Levy G. Pharmacokinetics of theophylline in children with asthma. Pediatrics. 1976 Oct;58(4):542–547. [PubMed] [Google Scholar]
- Hambleton G., Weinberger M., Taylor J., Cavanaugh M., Ginchansky E., Godfrey S., Tooley M., Bell T., Greenberg S. Comparison of cromoglycate (cromolyn) and theophylline in controlling symptoms of chronic asthma. A collaborative study. Lancet. 1977 Feb 19;1(8008):381–385. doi: 10.1016/s0140-6736(77)92601-0. [DOI] [PubMed] [Google Scholar]
- Simons F. E., Luciuk G. H., Simons K. J. Sustained-release theophylline for treatment of asthma in preschool children. Am J Dis Child. 1982 Sep;136(9):790–793. doi: 10.1001/archpedi.1982.03970450032008. [DOI] [PubMed] [Google Scholar]
- Wilson N., Silverman M. Controlled trial of slow-release aminophylline in childhood asthma: are short-term trials valid? Br Med J (Clin Res Ed) 1982 Mar 20;284(6319):863–866. doi: 10.1136/bmj.284.6319.863. [DOI] [PMC free article] [PubMed] [Google Scholar]