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. 1985 Aug;60(8):710–713. doi: 10.1136/adc.60.8.710

Prevention of intraventricular haemorrhage by fresh frozen plasma.

D W Beverley, T J Pitts-Tucker, P J Congdon, R J Arthur, G Tate
PMCID: PMC1777434  PMID: 3899020

Abstract

Seventy three preterm infants weighing less than 1500 g or less than 32 weeks' gestation, or both, were allocated randomly to treatment (fresh frozen plasma 10 ml/kg on admission and at 24 hours of age) or control groups. Fifteen (41%) out of 37 control patients sustained intraventricular haemorrhage compared with five (14%) of 36 patients receiving treatment (X2 = 5.24, P = 0.022). No difference was found in coagulation factors measured at birth or at 48 hours of age in both groups. Fresh frozen plasma appears to have a beneficial effect in the prevention of intraventricular haemorrhage.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beverley D. W., Chance G. W., Coates C. F. Intraventricular haemorrhage--timing of occurrence and relationship to perinatal events. Br J Obstet Gynaecol. 1984 Oct;91(10):1007–1013. doi: 10.1111/j.1471-0528.1984.tb03679.x. [DOI] [PubMed] [Google Scholar]
  2. Beverley D. W., Chance G. W., Inwood M. J., Schaus M., O'Keefe B. Intraventricular haemorrhage and haemostasis defects. Arch Dis Child. 1984 May;59(5):444–448. doi: 10.1136/adc.59.5.444. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Chiswick M. L., Johnson M., Woodhall C., Gowland M., Davies J., Toner N., Sims D. G. Protective effect of vitamin E (DL-alpha-tocopherol) against intraventricular haemorrhage in premature babies. Br Med J (Clin Res Ed) 1983 Jul 9;287(6385):81–84. doi: 10.1136/bmj.287.6385.81. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Donn S. M., Roloff D. W., Goldstein G. W. Prevention of intraventricular haemorrhage in preterm infants by phenobarbitone. A controlled trial. Lancet. 1981 Aug 1;2(8240):215–217. doi: 10.1016/s0140-6736(81)90470-0. [DOI] [PubMed] [Google Scholar]
  5. Gray O. P., Ackerman A., Fraser A. J. Intracranial haemorrhage and clotting defects in low-birth-weight infants. Lancet. 1968 Mar 16;1(7542):545–548. doi: 10.1016/s0140-6736(68)92827-4. [DOI] [PubMed] [Google Scholar]
  6. Hittner H. M., Godio L. B., Rudolph A. J., Adams J. M., Garcia-Prats J. A., Friedman Z., Kautz J. A., Monaco W. A. Retrolental fibroplasia: efficacy of vitamin E in a double-blind clinical study of preterm infants. N Engl J Med. 1981 Dec 3;305(23):1365–1371. doi: 10.1056/NEJM198112033052301. [DOI] [PubMed] [Google Scholar]
  7. Johnson C. A., Snyder M. S., Weaver R. L. Effects of fresh frozen plasma infusions on coagulation screening tests in neonates. Arch Dis Child. 1982 Dec;57(12):950–952. doi: 10.1136/adc.57.12.950. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Krishnamoorthy K. S., Shannon D. C., DeLong G. R., Todres I. D., Davis K. R. Neurologic sequelae in the survivors of neonatal intraventricular hemorrhage. Pediatrics. 1979 Aug;64(2):233–237. [PubMed] [Google Scholar]
  9. McDonald M. M., Johnson M. L., Rumack C. M., Koops B. L., Guggenheim M. A., Babb C., Hathaway W. E. Role of coagulopathy in newborn intracranial hemorrhage. Pediatrics. 1984 Jul;74(1):26–31. [PubMed] [Google Scholar]
  10. Ment L. R., Stewart W. B., Scott D. T., Duncan C. C. Beagle puppy model of intraventricular hemorrhage: randomized indomethacin prevention trial. Neurology. 1983 Feb;33(2):179–184. doi: 10.1212/wnl.33.2.179. [DOI] [PubMed] [Google Scholar]
  11. Morgan M. E., Benson J. W., Cooke R. W. Ethamsylate reduces the incidence of periventricular haemorrhage in very low birth-weight babies. Lancet. 1981 Oct 17;2(8251):830–831. doi: 10.1016/s0140-6736(81)91103-x. [DOI] [PubMed] [Google Scholar]
  12. Papile L. A., Burstein J., Burstein R., Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr. 1978 Apr;92(4):529–534. doi: 10.1016/s0022-3476(78)80282-0. [DOI] [PubMed] [Google Scholar]
  13. Papile L. A., Munsick-Bruno G., Schaefer A. Relationship of cerebral intraventricular hemorrhage and early childhood neurologic handicaps. J Pediatr. 1983 Aug;103(2):273–277. doi: 10.1016/s0022-3476(83)80366-7. [DOI] [PubMed] [Google Scholar]
  14. Perlman J. M., McMenamin J. B., Volpe J. J. Fluctuating cerebral blood-flow velocity in respiratory-distress syndrome. Relation to the development of intraventricular hemorrhage. N Engl J Med. 1983 Jul 28;309(4):204–209. doi: 10.1056/NEJM198307283090402. [DOI] [PubMed] [Google Scholar]
  15. Setzer E. S., Webb I. B., Wassenaar J. W., Reeder J. D., Mehta P. S., Eitzman D. V. Platelet dysfunction and coagulopathy in intraventricular hemorrhage in the premature infant. J Pediatr. 1982 Apr;100(4):599–605. doi: 10.1016/s0022-3476(82)80766-x. [DOI] [PubMed] [Google Scholar]
  16. Shankaran S., Slovis T. L., Bedard M. P., Poland R. L. Sonographic classification of intracranial hemorrhage. A prognostic indicator of mortality, morbidity, and short-term neurologic outcome. J Pediatr. 1982 Mar;100(3):469–475. doi: 10.1016/s0022-3476(82)80462-9. [DOI] [PubMed] [Google Scholar]
  17. Tarby T. J., Volpe J. J. Intraventricular hemorrhage in the premature infant. Pediatr Clin North Am. 1982 Oct;29(5):1077–1104. doi: 10.1016/s0031-3955(16)34248-1. [DOI] [PubMed] [Google Scholar]
  18. Thomas D. B., Burnard E. D. Prevention of intraventricular haemorrhage in babies receiving artificial ventilation. Med J Aust. 1973 May 12;1(19):933–936. [PubMed] [Google Scholar]
  19. Turner T., Prowse C. V., Prescott R. J., Cash J. D. A clinical trial on the early detection and correction of haemostatic defects in selected high-risk neonates. Br J Haematol. 1981 Jan;47(1):65–75. doi: 10.1111/j.1365-2141.1981.tb02762.x. [DOI] [PubMed] [Google Scholar]
  20. Volpe J. J. Neonatal intraventricular hemorrhage. N Engl J Med. 1981 Apr 9;304(15):886–891. doi: 10.1056/NEJM198104093041506. [DOI] [PubMed] [Google Scholar]

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