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. 1985 Sep;60(9):814–818. doi: 10.1136/adc.60.9.814

Plasma concentrations after oral or intramuscular vitamin K1 in neonates.

A W McNinch, C Upton, M Samuels, M J Shearer, P McCarthy, J H Tripp, R L'E Orme
PMCID: PMC1777471  PMID: 4051538

Abstract

One hundred and seven healthy, breast fed infants received 1 mg vitamin K1 either at birth (orally or intramuscularly) or with the first feed (orally). Venous blood samples collected in the next 24 hours were assayed for plasma vitamin K1. In babies given the vitamin orally at birth, the peak median concentration (73 ng/ml) occurred at four hours. By 24 hours median plasma concentrations had fallen to 23 ng/ml and 35 ng/ml in the groups fed vitamin K1 at birth or with the first feed, respectively; this difference was not, however, significant. Plasma concentrations after intramuscular injection exceeded those in the oral groups at all comparable times, with a peak median concentration of 1781 ng/ml at 12 hours falling to 444 ng/ml at 24 hours. Since median plasma vitamin K1 concentrations 24 hours after oral administration were some 100 times and 1000 times greater than previously estimated adult and newborn values respectively, this study supports giving vitamin K1 orally at birth to well, mature babies to protect against early haemorrhagic disease of the newborn. Further studies are needed to determine the optimum dose for protection over subsequent weeks.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Dunn P. M. Vitamin K1 for all newborn babies. Lancet. 1982 Oct 2;2(8301):770–770. doi: 10.1016/s0140-6736(82)90953-9. [DOI] [PubMed] [Google Scholar]
  2. Forbes D. Delayed presentation of haemorrhagic disease of the newborn. Med J Aust. 1983 Aug 6;2(3):136–138. doi: 10.5694/j.1326-5377.1983.tb122364.x. [DOI] [PubMed] [Google Scholar]
  3. Haroon Y., Shearer M. J., Rahim S., Gunn W. G., McEnery G., Barkhan P. The content of phylloquinone (vitamin K1) in human milk, cows' milk and infant formula foods determined by high-performance liquid chromatography. J Nutr. 1982 Jun;112(6):1105–1117. doi: 10.1093/jn/112.6.1105. [DOI] [PubMed] [Google Scholar]
  4. Keenan W. J., Jewett T., Glueck H. I. Role of feeding and vitamin K in hypoprothrombinemia of the newborn. Am J Dis Child. 1971 Apr;121(4):271–277. doi: 10.1001/archpedi.1971.02100150045001. [DOI] [PubMed] [Google Scholar]
  5. Lane P. A., Hathaway W. E., Githens J. H., Krugman R. D., Rosenberg D. A. Fatal intracranial hemorrhage in a normal infant secondary to vitamin K deficiency. Pediatrics. 1983 Oct;72(4):562–564. [PubMed] [Google Scholar]
  6. McNinch A. W., Orme R. L., Tripp J. H. Haemorrhagic disease of the newborn returns. Lancet. 1983 May 14;1(8333):1089–1090. doi: 10.1016/s0140-6736(83)91921-9. [DOI] [PubMed] [Google Scholar]
  7. O'Connor M. E., Livingstone D. S., Hannah J., Wilkins D. Vitamin K deficiency and breast-feeding. Am J Dis Child. 1983 Jun;137(6):601–602. doi: 10.1001/archpedi.1983.02140320077020. [DOI] [PubMed] [Google Scholar]
  8. Shearer M. J., Barkhan P., Webster G. R. Absorption and excretion of an oral dose of tritiated vitamin K1 in man. Br J Haematol. 1970 Mar;18(3):297–308. doi: 10.1111/j.1365-2141.1970.tb01444.x. [DOI] [PubMed] [Google Scholar]
  9. Shearer M. J. High-performance liquid chromatography of K vitamins and their antagonists. Adv Chromatogr. 1983;21:243–301. [PubMed] [Google Scholar]
  10. Shearer M. J., Mallinson C. N., Webster G. R., Barkhan P. Clearance from plasma and excretion in urine, faeces and bile of an intravenous dose of tritiated vitamin K 1 in man. Br J Haematol. 1972 May;22(5):579–588. doi: 10.1111/j.1365-2141.1972.tb05704.x. [DOI] [PubMed] [Google Scholar]
  11. Shearer M. J., Rahim S., Barkhan P., Stimmler L. Plasma vitamin K1 in mothers and their newborn babies. Lancet. 1982 Aug 28;2(8296):460–463. doi: 10.1016/s0140-6736(82)90493-7. [DOI] [PubMed] [Google Scholar]
  12. Sutherland J. M., Glueck H. I., Gleser G. Hemorrhagic disease of the newborn. Breast feeding as a necessary factor in the pathogenesis. Am J Dis Child. 1967 May;113(5):524–533. doi: 10.1001/archpedi.1967.02090200056003. [DOI] [PubMed] [Google Scholar]
  13. WEFRING K. W. Hemorrhage in the newborn and vitamin K prophylaxis. J Pediatr. 1962 Nov;61:686–692. doi: 10.1016/s0022-3476(62)80339-4. [DOI] [PubMed] [Google Scholar]

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