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. 1985 Oct;60(10):929–931. doi: 10.1136/adc.60.10.929

Tubular dysfunction in type I diabetes mellitus.

M Miltényi, A Körner, T Tulassay, A Szabó
PMCID: PMC1777521  PMID: 3933437

Abstract

Tubular function was investigated in patients with diabetic ketoacidosis and those with poorly controlled type I diabetes. Urinary excretion of beta 2 microglobulin and that of certain enzymes: gamma glutamyltransferase, leucine aminopeptidase, and N-acetyl-beta-D-glucosaminidase activities were significantly raised during ketoacidosis in 11 patients compared with healthy controls. In 13 poorly controlled diabetics, tubular electrolyte transport was studied and a significant reduction in tubular phosphate and sodium reabsorption was found. Tubular dysfunction occurring during diabetic ketoacidosis and in poorly controlled diabetics may contribute to the development of diabetic nephropathy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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