Abstract
In a double blind, partial crossover trial we compared treatment with prednisolone with treatment with placebo (56 treatments) in 38 children aged less than 18 months (mean age 9.8 months, range 3-17 months), 30 of whom had required previous admission to hospital. Placebo or oral prednisolone 2 mg/kg/day in two divided doses for five days was given during acute exacerbations of symptoms on an outpatient basis. Daily symptom scores of cough, wheeze, and breathlessness did not show any significant difference in rate of improvement or overall outcome, either between the two whole groups or within subgroups aged less than 6 months, 6-12 months, and 12-18 months. Parental preference failed to indicate superiority of treatment with prednisolone over treatment with placebo in the 18 crossover patients, and parents were equally as likely to feel that treatment with either placebo or prednisolone had had positive effect in non-crossover patients. Two children required admission to hospital during treatment, one aged 5 1/2 months being treated with prednisolone, and one aged 14 months being treated with placebo.
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- Dabbous I. A., Tkachyk J. S., Stamm S. J. A double blind study on the effects of corticosteroids in the treatment of bronchiolitis. Pediatrics. 1966 Mar;37(3):477–484. [PubMed] [Google Scholar]
- Ellul-Micallef R., Borthwick R. C., McHardy G. J. The time-course of response to prednisolone in chronic bronchial asthma. Clin Sci Mol Med. 1974 Aug;47(2):105–117. doi: 10.1042/cs0470105. [DOI] [PubMed] [Google Scholar]
- Ellul-Micallef R., Fenech F. F. Intravenous prednisolone in chronic bronchial asthma. Thorax. 1975 Jun;30(3):312–315. doi: 10.1136/thx.30.3.312. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Grant I. W. Are corticosteroids necessary in the treatment of severe acute asthma? Br J Dis Chest. 1982 Apr;76(2):125–129. [PubMed] [Google Scholar]
- Harfi H., Hanissian A. S., Crawford L. V. Treatment of status asthmaticus in children with high doses and conventional doses of methylprednisolone. Pediatrics. 1978 Jun;61(6):829–831. [PubMed] [Google Scholar]
- Kattan M., Gurwitz D., Levison H. Corticosteroids in status asthmaticus. J Pediatr. 1980 Mar;96(3 Pt 2):596–599. doi: 10.1016/s0022-3476(80)80872-9. [DOI] [PubMed] [Google Scholar]
- Leer J. A., Jr, Green J. L., Heimlich E. M., Hyde J. S., Moffet H. L., Young G. A., Barron B. A. Corticosteroid treatment in bronchiolitis. A controlled, collaborative study in 297 infants and children. Am J Dis Child. 1969 May;117(5):495–503. [PubMed] [Google Scholar]
- Luksza A. R. Acute severe asthma treated without steroids. Br J Dis Chest. 1982 Jan;76(1):15–19. [PubMed] [Google Scholar]
- Pierson W. E., Bierman C. W., Kelley V. C. A double-blind trial of corticosteroid therapy in status asthmaticus. Pediatrics. 1974 Sep;54(3):282–288. [PubMed] [Google Scholar]
- Silverman M. Bronchodilators for wheezy infants? Arch Dis Child. 1984 Jan;59(1):84–87. doi: 10.1136/adc.59.1.84. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Speight A. N., Lee D. A., Hey E. N. Underdiagnosis and undertreatment of asthma in childhood. Br Med J (Clin Res Ed) 1983 Apr 16;286(6373):1253–1256. doi: 10.1136/bmj.286.6373.1253. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tal A., Bavilski C., Yohai D., Bearman J. E., Gorodischer R., Moses S. W. Dexamethasone and salbutamol in the treatment of acute wheezing in infants. Pediatrics. 1983 Jan;71(1):13–18. [PubMed] [Google Scholar]