Skip to main content
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1986 Feb;61(2):186–188. doi: 10.1136/adc.61.2.186

Plasma concentrations of clonazepam after single rectal administration.

G W Rylance, J Poulton, R C Cherry, R E Cullen
PMCID: PMC1777570  PMID: 3954443

Abstract

Clonazepam was administered rectally to six children aged 1.4 to 4.7 years in a dose of 0.05 mg/kg and to five children aged 1.4 to 4.1 years in a dose of 0.1 mg/kg. Plasma concentrations indicate that it is rapidly absorbed, and it may therefore be an alternative to rectal administration of diazepam in continuing convulsions.

Full text

PDF
186

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Agurell S., Berlin A., Ferngren H., Hellström B. Plasma levels of diazepam after parenteral and rectal administration in children. Epilepsia. 1975 Jun;16(2):277–283. doi: 10.1111/j.1528-1157.1975.tb06058.x. [DOI] [PubMed] [Google Scholar]
  2. Bamberger P., Matthes A. Eine neue Therapiemöglichkeit des Status epilepticus im Kindesalter mit Valium i.v. Z Kinderheilkd. 1966 Jan 17;95(2):155–163. [PubMed] [Google Scholar]
  3. Bladin P. F. The use of clonazepam as an anticonvulsant--clinical evaluation. Med J Aust. 1973 Apr 7;1(14):683–688. [PubMed] [Google Scholar]
  4. Congdon P. J., Forsythe W. I. Intravenous clonazepam in the treatment of status epilepticus in children. Epilepsia. 1980 Feb;21(1):97–102. doi: 10.1111/j.1528-1157.1980.tb04049.x. [DOI] [PubMed] [Google Scholar]
  5. Dreifuss F. E., Penry J. K., Rose S. W., Kupferberg H. J., Dyken P., Sato S. Serum clonazepam concentrations in children with absence seizures. Neurology. 1975 Mar;25(3):255–258. doi: 10.1212/wnl.25.3.255. [DOI] [PubMed] [Google Scholar]
  6. Ferngren H. G. Diazepam treatment for acute convulsions in children. A report of 41 patients, three with plasma levels. Epilepsia. 1974 Mar;15(1):27–37. doi: 10.1111/j.1528-1157.1974.tb03994.x. [DOI] [PubMed] [Google Scholar]
  7. Klosterskov Jensen P., Abild K., Nøhr Poulsen M. Serum concentration of clonazepam after rectal administration. Acta Neurol Scand. 1983 Dec;68(6):417–420. doi: 10.1111/j.1600-0404.1983.tb04852.x. [DOI] [PubMed] [Google Scholar]
  8. Knudsen F. U. Plasma-diazepam in infants after rectal administration in solution and by suppository. Acta Paediatr Scand. 1977 Sep;66(5):563–567. doi: 10.1111/j.1651-2227.1977.tb07947.x. [DOI] [PubMed] [Google Scholar]
  9. Pinder R. M., Brogden R. N., Speight T. M., Avery G. S. Clonazepam: a review of its pharmacological properties and therapeutic efficacy in epilepsy. Drugs. 1976 Nov;12(5):321–361. doi: 10.2165/00003495-197612050-00001. [DOI] [PubMed] [Google Scholar]
  10. Rutter N., Metcalfe D. H. Febrile convulsions--what do parents do? Br Med J. 1978 Nov 11;2(6148):1345–1346. doi: 10.1136/bmj.2.6148.1345. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Ståhl Y., Persson A., Petters I., Rane A., Theorell K., Walson P. Kinetics of clonazepam in relation to electroencephalographic and clinical effects. Epilepsia. 1983 Apr;24(2):225–231. doi: 10.1111/j.1528-1157.1983.tb04883.x. [DOI] [PubMed] [Google Scholar]
  12. de Boer A. G., Röst-Kaiser J., Bracht H., Breimer D. D. Assay of underivatized intrazepam and clonazepam in plasma by capillary gas chromatography applied to pharmacokinetic and bioavailability studies in humans. J Chromatogr. 1978 Jan 1;145(1):105–114. doi: 10.1016/s0378-4347(00)81672-2. [DOI] [PubMed] [Google Scholar]
  13. de Silva J. A., Bekersky I. Determination of clonazepam and flunitrazepam in blood by electron-capture gas-liquid chromatography. J Chromatogr. 1974 Nov 6;99(0):447–460. doi: 10.1016/s0021-9673(00)90876-8. [DOI] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES