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. 1986 Mar;61(3):233–238. doi: 10.1136/adc.61.3.233

Early administration of indomethacin to preterm infants.

J M Rennie, J Doyle, R W Cooke
PMCID: PMC1777724  PMID: 3516077

Abstract

Indomethacin (0.2 mg/kg) or saline was given intravenously during the first 24 hours to 50 preterm infants in a double blind controlled trial. Eight of the control group later required treatment with indomethacin for clinical signs of left to right shunt, but only one in the treatment group (p = 0.03). Treatment with indomethacin prolonged bleeding time, raised serum creatinine concentrations, and was associated with gastrointestinal haemorrhage in seven infants. Five of these had a serum indomethacin concentration greater than 1.0 microgram/ml. There was a significant reduction of the stable metabolite of prostacyclin, 6-ketoprostaglandin F1 alpha, commencing six hours after treatment and lasting for four days. There was no significant difference in the incidence of intraventricular haemorrhage, days of treatment with oxygen or ventilation, or mortality between the two groups.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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