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. 1986 Jun;61(6):585–588. doi: 10.1136/adc.61.6.585

Thrombopoietic activity in preterm newborns and infants.

L Sirota, H Bessler, Z Weissman, F Dulitzky, M Djaldetti
PMCID: PMC1777849  PMID: 3729528

Abstract

Platelet count and thrombopoietic activity were investigated in preterm infants at birth and during their first four months of life. Thrombopoiesis stimulating factor activity in cord serum was significantly lower than that of adults and of the respective mothers. No difference was noted between thrombopoietic activity in cord serum in the various gestational ages studied--that is, 24 through 39 weeks. Preterm infants followed during their first four months of life showed a mean platelet count significantly higher than that observed in term infants at the respective age. Furthermore, thrombocytosis was found in premature thriving infants at the age of 1 and 2 months. It is suggested that this thrombocytosis is responsible for the low thrombopoietic activity observed in these infants during their first four months of life.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aballi A. J., Puapondh Y., Desposito F. Platelet counts in thriving premature infants. Pediatrics. 1968 Oct;42(4):685–689. [PubMed] [Google Scholar]
  2. Addiego J. E., Jr, Mentzer W. C., Jr, Dallman P. R. Thrombocytosis in infants and children. J Pediatr. 1974 Dec;85(6):805–807. doi: 10.1016/s0022-3476(74)80345-8. [DOI] [PubMed] [Google Scholar]
  3. Bessler H., Sirota L., Weissman Z., Dulitzky F., Djaldetti M. Thrombopoietic activity in newborn infants. Biol Neonate. 1986;49(2):61–65. doi: 10.1159/000242511. [DOI] [PubMed] [Google Scholar]
  4. Ebbe S., Stohlman F., Jr, Donovan J., Overcash J. Megakaryocyte maturation rate in thrombocytopenic rats. Blood. 1968 Nov;32(5):787–795. [PubMed] [Google Scholar]
  5. Freedman M. H., McDonald T. P., Saunders E. F. Differentiation of murine marrow megakaryocyte progenitors (CFUm): humoral control in vitro. Cell Tissue Kinet. 1981 Jan;14(1):53–58. doi: 10.1111/j.1365-2184.1981.tb00510.x. [DOI] [PubMed] [Google Scholar]
  6. Hoffman R., Mazur E., Bruno E., Floyd V. Assay of an activity in the serum of patients with disorders of thrombopoiesis that stimulates formation of megakaryocytic colonies. N Engl J Med. 1981 Sep 3;305(10):533–538. doi: 10.1056/NEJM198109033051001. [DOI] [PubMed] [Google Scholar]
  7. Levin J., Evatt B. L. Humoral control of thrombopoiesis. Blood Cells. 1979 Mar 23;5(1):105–121. [PubMed] [Google Scholar]
  8. Lundström U. Thrombocytosis in low birthweight infants: a physiological phenomenon in infancy. Arch Dis Child. 1979 Sep;54(9):715–717. doi: 10.1136/adc.54.9.715. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. McDonald T. P. Bioassay for thrombopoietin utilizing mice in rebound thrombocytosis. Proc Soc Exp Biol Med. 1973 Dec;144(3):1006–1012. doi: 10.3181/00379727-144-37730. [DOI] [PubMed] [Google Scholar]
  10. Meberg A., Jakobsen E., Halvorsen K. Humoral regulation of erythropoiesis and thrombopoiesis in appropriate and small for gestational age infants. Acta Paediatr Scand. 1982 Sep;71(5):769–773. doi: 10.1111/j.1651-2227.1982.tb09517.x. [DOI] [PubMed] [Google Scholar]
  11. Penington D. G. Isotope bioassay for "thrombopoietin". Br Med J. 1970 Mar 7;1(5696):606–608. doi: 10.1136/bmj.1.5696.606. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Shreiner D. P., Weinberg J., Enoch D. Plasma thrombopoietic activity in humans with normal and abnormal platelet counts. Blood. 1980 Aug;56(2):183–188. [PubMed] [Google Scholar]
  13. Stockman J. A. Anemia of prematurity. Semin Hematol. 1975 Apr;12(2):163–173. [PubMed] [Google Scholar]

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