Skip to main content
PMC home page
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1986 Aug;61(8):744–749. doi: 10.1136/adc.61.8.744

Restricted feeding and human intestinal plasma cell development.

W F Knox
PMCID: PMC1777918  PMID: 3090947

Abstract

Small intestinal mucosa from 129 necropsies and 15 surgical specimens from infants aged from birth to 21 months was examined for the presence of cells containing IgA, IgM, and IgG using the PAP immunoperoxidase technique. Immunoglobulin containing cells were nearly always absent in infants under 1 week of age but occurred in the second week of life in infants who had had milk feeds. At this time, IgM containing cells were predominant, but IgA containing cells were more numerous by the sixth week. IgG containing cells were generally sparse. Parenterally fed infants who had received little or no intestinal milk showed significantly fewer immunoglobulin containing cells than those who had been fed normally, irrespective of gestation. Lack of stimulation by food and bacterial antigens may contribute to immunoglobulin containing cells failing to occur in these parenterally fed neonates.

Full text

PDF
744

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. APLEY J. Primary myocardial disease in infancy: clinical aspects. Arch Dis Child. 1961 Aug;36:366–372. doi: 10.1136/adc.36.188.366. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BRIDGES R. A., CONDIE R. M., ZAK S. J., GOOD R. A. The morphologic basis of antibody formation development during the neonatal period. J Lab Clin Med. 1959 Mar;53(3):331–357. [PubMed] [Google Scholar]
  3. Berg T. Immunoglobulin levels in infants with low birth weights. Acta Paediatr Scand. 1968 Sep;57(5):369–376. doi: 10.1111/j.1651-2227.1968.tb07307.x. [DOI] [PubMed] [Google Scholar]
  4. Binder V. Cell density in lamina propria of the colon. A quantitative method applied to normal subjects and ulcerative colitis patients. Scand J Gastroenterol. 1970;5(6):485–490. [PubMed] [Google Scholar]
  5. Brandtzaeg P., Baklien K. Immunoglobulin-producing cells in the intestine in health and disease. Clin Gastroenterol. 1976 May;5(2):251–269. [PubMed] [Google Scholar]
  6. Burns J. Background staining and sensitivity of the unlabelled antibody-enzyme (PAP) method. Comparison with the peroxidase labelled antibody sandwich method using formalin fixed paraffin embedded material. Histochemistry. 1975 Jun 5;43(3):291–294. doi: 10.1007/BF00499711. [DOI] [PubMed] [Google Scholar]
  7. Conway S. P., Dear P. R., Smith I. Immunoglobulin profile of the preterm baby. Arch Dis Child. 1985 Mar;60(3):208–212. doi: 10.1136/adc.60.3.208. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Ferguson A., Parrott D. M. The effect of antigen deprivation on thymus-dependent and thymus-independent lymphocytes in the small intestine of the mouse. Clin Exp Immunol. 1972 Dec;12(4):477–488. [PMC free article] [PubMed] [Google Scholar]
  9. Green F., Heyworth B. Immunoglobulin-containing cells in jejunal mucosa of children with protein-energy malnutrition and gastroenteritis. Arch Dis Child. 1980 May;55(5):380–383. doi: 10.1136/adc.55.5.380. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Haworth J. C., Dilling L. Concentration of gamma-A-globulin in serum, saliva, and nasopharyngeal secretions of infants and children. J Lab Clin Med. 1966 Jun;67(6):922–933. [PubMed] [Google Scholar]
  11. Husband A. J., Gowans J. L. The origin and antigen-dependent distribution of IgA-containing cells in the intestine. J Exp Med. 1978 Nov 1;148(5):1146–1160. doi: 10.1084/jem.148.5.1146. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Maffei H. V., Kingston D., Hill I. D., Shiner M. Histopathologic changes and the immune response within the jejunal mucosa in infants and children. Pediatr Res. 1979 Jun;13(6):733–736. doi: 10.1203/00006450-197906000-00002. [DOI] [PubMed] [Google Scholar]
  13. Perkkiö M., Savilahti E. Time of appearance of immunoglobulin-containing cells in the mucosa of the neonatal intestine. Pediatr Res. 1980 Aug;14(8):953–955. doi: 10.1203/00006450-198008000-00012. [DOI] [PubMed] [Google Scholar]
  14. Petit J. C., Galinha A., Salomon J. C. Immunoglobulins in the intestinal content of the human fetus with special reference to IgA. Eur J Immunol. 1973 Jun;3(6):373–375. doi: 10.1002/eji.1830030611. [DOI] [PubMed] [Google Scholar]
  15. Rieger C. H., Rothberg R. M. Development of the capacity to produce specific antibody to an ingested food antigen in the premature infant. J Pediatr. 1975 Oct;87(4):515–518. doi: 10.1016/s0022-3476(75)80811-0. [DOI] [PubMed] [Google Scholar]
  16. Roberts S. A., Freed D. L. Neonatal IgA secretion enhanced by breast feeding. Lancet. 1977 Nov 26;2(8048):1131–1131. doi: 10.1016/s0140-6736(77)90576-1. [DOI] [PubMed] [Google Scholar]
  17. Rothberg R. M. Immunoglobulin and specific antibody synthesis during the first weeks of life of premature infants. J Pediatr. 1969 Sep;75(3):391–399. doi: 10.1016/s0022-3476(69)80264-7. [DOI] [PubMed] [Google Scholar]
  18. Sagie E., Tarabulus J., Maeir D. M., Freier S. Diet and development of intestinal IgA in the mouse. Isr J Med Sci. 1974 May;10(5):532–534. [PubMed] [Google Scholar]
  19. Savilahti E. Immunoglobulin-containing cells in the intestinal mucosa and immunoglobulins in the intestinal juice in children. Clin Exp Immunol. 1972 Jul;11(3):415–425. [PMC free article] [PubMed] [Google Scholar]
  20. Selner J. C., Merrill D. A., Claman H. N. Salivary immunoglobulin and albumin: development during the newborn period. J Pediatr. 1968 May;72(5):685–689. doi: 10.1016/s0022-3476(68)80014-9. [DOI] [PubMed] [Google Scholar]
  21. Skinner J. M., Whitehead R. Morphological methods in the study of the gut immune system in man. J Clin Pathol. 1976 Jun;29(6):564–567. doi: 10.1136/jcp.29.6.564. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Wade S., Lemonnier D., Alexiu A., Bocquet L. Effect of early postnatal under- and overnutrition on the development of IgA plasma cells in mouse gut. J Nutr. 1982 Jun;112(6):1047–1051. doi: 10.1093/jn/112.6.1047. [DOI] [PubMed] [Google Scholar]
  23. Wijesinha S. S., Steer H. W. Studies of the immunoglobulin-producing cells of the human intestine: the defunctioned bowel. Gut. 1982 Mar;23(3):211–214. doi: 10.1136/gut.23.3.211. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES