Skip to main content
PMC home page
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1986 Sep;61(9):832–842. doi: 10.1136/adc.61.9.832

Prognostic value of different staging systems in neuroblastomas and completeness of tumour excision.

N L Carlsen, I J Christensen, H Schroeder, P V Bro, U Hesselbjerg, K B Jensen, O H Nielsen
PMCID: PMC1778021  PMID: 3767412

Abstract

Two hundred and fifty three patients were retrospectively assigned to eight different staging systems proposed for neuroblastomas, and the prognostic value of each staging system was evaluated individually. The ability of each system to predict prognosis was compared with the others and the system proposed by Evans et al found to be the best predictor, even better than the recently proposed Tumour-Nodes-Metastases staging system. This is probably due to the fact that factors other than the resectability of the tumour play a major role in the survival of these children. Age was found to have independent prognostic significance whatever staging system was used.

Full text

PDF
832

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BECKWITH J. B., PERRIN E. V. IN SITU NEUROBLASTOMAS: A CONTRIBUTION TO THE NATURAL HISTORY OF NEURAL CREST TUMORS. Am J Pathol. 1963 Dec;43:1089–1104. [PMC free article] [PubMed] [Google Scholar]
  2. Beckwith J. B., Martin R. F. Observations on the histopathology of neuroblastomas. J Pediatr Surg. 1968 Feb;3(1):106–110. doi: 10.1016/0022-3468(68)90989-5. [DOI] [PubMed] [Google Scholar]
  3. Breslow N., McCann B. Statistical estimation of prognosis for children with neuroblastoma. Cancer Res. 1971 Dec;31(12):2098–2103. [PubMed] [Google Scholar]
  4. Carlsen N. L., Schroeder H., Bro P. V., Erichsen G., Hamborg-Pedersen B., Jensen K. B., Nielsen O. H. Neuroblastomas treated at the four major child oncologic clinics in Denmark 1943-1980: an evaluation of 180 cases. Med Pediatr Oncol. 1985;13(4):180–186. doi: 10.1002/mpo.2950130404. [DOI] [PubMed] [Google Scholar]
  5. Evans A. E., Albo V., D'Angio G. J., Finklestein J. Z., Leiken S., Santulli T., Weiner J., Hammond G. D. Factors influencing survival of children with nonmetastatic neuroblastoma. Cancer. 1976 Aug;38(2):661–666. doi: 10.1002/1097-0142(197608)38:2<661::aid-cncr2820380206>3.0.co;2-m. [DOI] [PubMed] [Google Scholar]
  6. Evans A. E., Baum E., Chard R. Do infants with stage IV-S neuroblastoma need treatment? Arch Dis Child. 1981 Apr;56(4):271–274. doi: 10.1136/adc.56.4.271. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Evans A. E., D'Angio G. J., Koop C. E. The role of multimodal therapy in patients with local and regional neuroblastoma. J Pediatr Surg. 1984 Feb;19(1):77–80. doi: 10.1016/s0022-3468(84)80021-4. [DOI] [PubMed] [Google Scholar]
  8. Evans A. E., D'Angio G. J., Randolph J. A proposed staging for children with neuroblastoma. Children's cancer study group A. Cancer. 1971 Feb;27(2):374–378. doi: 10.1002/1097-0142(197102)27:2<374::aid-cncr2820270221>3.0.co;2-g. [DOI] [PubMed] [Google Scholar]
  9. Green A. A., Hustu H. O., Palmer R., Pinkel D. Total-body sequential segmental irradiation and combination chemotherapy for children with disseminated neuroblastoma. Cancer. 1976 Dec;38(6):2250–2257. doi: 10.1002/1097-0142(197612)38:6<2250::aid-cncr2820380610>3.0.co;2-7. [DOI] [PubMed] [Google Scholar]
  10. Grosfeld J. L., Ballantine T. V., Baehner R. L. Experience with "second-look" operations in pediatric solid tumors. J Pediatr Surg. 1978 Jun;13(3):275–280. doi: 10.1016/s0022-3468(78)80400-x. [DOI] [PubMed] [Google Scholar]
  11. Hassenbusch S., Kaizer H., White J. J. Prognostic factors in neuroblastic tumors. J Pediatr Surg. 1976 Jun;11(3):287–297. doi: 10.1016/s0022-3468(76)80181-9. [DOI] [PubMed] [Google Scholar]
  12. Hayes F. A., Green A., Hustu H. O., Kumar M. Surgicopathologic staging of neuroblastoma: prognostic significance of regional lymph node metastases. J Pediatr. 1983 Jan;102(1):59–62. doi: 10.1016/s0022-3476(83)80287-x. [DOI] [PubMed] [Google Scholar]
  13. James D. J., Jr Proposed classification of neuroblastoma. J Pediatr. 1967 Nov;71(5):764–764. doi: 10.1016/s0022-3476(67)80219-1. [DOI] [PubMed] [Google Scholar]
  14. Koop C. E., Johnson D. G. Neuroblastoma: an assessment of therapy in reference to staging. J Pediatr Surg. 1971 Oct;6(5):595–600. doi: 10.1016/0022-3468(71)90384-8. [DOI] [PubMed] [Google Scholar]
  15. Le Tourneau J. N., Bernard J. L., Hendren W. H., Carcassonne M. Evaluation of the role of surgery in 130 patients with neuroblastoma. J Pediatr Surg. 1985 Jun;20(3):244–249. doi: 10.1016/s0022-3468(85)80113-5. [DOI] [PubMed] [Google Scholar]
  16. Ninane J., Pritchard J., Morris Jones P. H., Mann J. R., Malpas J. S. Stage II neuroblastoma. Adverse prognostic significance of lymph node involvement. Arch Dis Child. 1982 Jun;57(6):438–442. doi: 10.1136/adc.57.6.438. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Pinkel D., Pratt C., Holton C., James D., Jr, Wrenn E., Jr, Hustu H. O. Survival of children with neuroblastoma treated with combination chemotherapy. J Pediatr. 1968 Dec;73(6):928–931. doi: 10.1016/s0022-3476(68)80252-5. [DOI] [PubMed] [Google Scholar]
  18. Rosen E. M., Cassady J. R., Frantz C. N., Kretschmar C. S., Levey R., Sallen S. E. Stage IV-N: a favorable subset of children with metastatic neuroblastoma. Med Pediatr Oncol. 1985;13(4):194–198. doi: 10.1002/mpo.2950130407. [DOI] [PubMed] [Google Scholar]
  19. Sandstedt B., Jereb B., Eklund G. Prognostic factors in neuroblastomas. Acta Pathol Microbiol Immunol Scand A. 1983 Sep;91(5):365–371. doi: 10.1111/j.1699-0463.1983.tb02767.x. [DOI] [PubMed] [Google Scholar]
  20. Sitarz A., Finklestein J., Grosfeld J., Leikin S., Mc Creadie S., Klemperer M., Bernstein I., Sather H., Hammond D. An evaluation of the role of surgery in disseminated neuroblastoma: a report from the Children's Cancer Study Group. J Pediatr Surg. 1983 Apr;18(2):147–151. doi: 10.1016/s0022-3468(83)80537-5. [DOI] [PubMed] [Google Scholar]
  21. Turkel S. B., Itabashi H. H. The natural history of neuroblastic cells in the fetal adrenal gland. Am J Pathol. 1974 Aug;76(2):225–244. [PMC free article] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES