Abstract
1 Angiotensin I (AI) and AII elicited a dose-dependent potentiation of contractions by rat vas deferens produced by low frequency nerve stimulation without enhancing the contraction produced by exogenous noradrenaline. The AII-induced presynaptic potentiation was blocked by the specific antagonist cysteine8-AII.
2 The vasoconstrictor response to periarterial stimulation of rat isolated perfused kidney was potentiated by AII and there was a lesser enhancement of the effect of exogenous noradrenaline.
3 The response to stimulation of complete sympathetic outflow from the spinal cord to blood vessels in the pithed rat was enhanced by angiotensin or vasopressin in direct proportion to the increase in prestimulus muscular tone. The blood pressure in the pithed rats is primarily maintained by the renin-angiotensin system since the converting-enzyme inhibitor (SQ-20881) or bilateral nephrectomy caused further substantial lowering of systemic blood pressure after spinal cord destruction and after treatment with curare and atropine.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BENELLI G., DELLABELLA D., GANDINI A. ANGIOTENSIN AND PERIPHERAL SYMPATHETIC NERVE ACTIVITY. Br J Pharmacol Chemother. 1964 Feb;22:211–219. doi: 10.1111/j.1476-5381.1964.tb01561.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bell C. Mechanism of enhancement by angiotensin II of sympathetic adrenergic transmission in the guinea pig. Circ Res. 1972 Sep;31(3):348–355. doi: 10.1161/01.res.31.3.348. [DOI] [PubMed] [Google Scholar]
- Ferreira S. H., Greene L. H., Alabaster V. A., Bakhle Y. S., Vane J. R. Activity of various fractions of bradykinin potentiating factor against angiotensin I converting enzyme. Nature. 1970 Jan 24;225(5230):379–380. doi: 10.1038/225379a0. [DOI] [PubMed] [Google Scholar]
- Gillespie J. S., Muir T. C. A method of stimulating the complete sympathetic outflow from the spinal cord to blood vessels in the pithed rat. Br J Pharmacol Chemother. 1967 May;30(1):78–87. doi: 10.1111/j.1476-5381.1967.tb02114.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kadowitz P. J., Sweet C. S., Brody M. J. Influence of angiotensin I, angiontensin II and cocaine on adrenergic vasoconstrictor responses in the dog hindpaw. J Pharmacol Exp Ther. 1972 Nov;183(2):275–283. [PubMed] [Google Scholar]
- Kadowitz P. J., Sweet C. S., Brody M. J. Potentiation of adrenergic venomotor responses by angiotensin, prostaglandin F 2 and cocaine. J Pharmacol Exp Ther. 1971 Jan;176(1):167–173. [PubMed] [Google Scholar]
- Needleman P., Johnson E. M., Jr, Vine W., Flanigan E., Marshall G. R. Pharmacology of antagonists of angiotensin I and II. Circ Res. 1972 Dec;31(6):862–867. doi: 10.1161/01.res.31.6.862. [DOI] [PubMed] [Google Scholar]
- REDLEAF P. D., TOBIAN L. The question of vascular hyper-responsiveness in hypertension. Circ Res. 1958 Mar;6(2):185–193. doi: 10.1161/01.res.6.2.185. [DOI] [PubMed] [Google Scholar]
- Türker R. K. Effect of angiotensin on the response to norepinephrine and peri-arterial stimulation of the isolated perfused cat terminal ileum. Eur J Pharmacol. 1973 Feb;21(2):171–177. doi: 10.1016/0014-2999(73)90222-7. [DOI] [PubMed] [Google Scholar]
- Zimmerman B. G. Evaluation of peripheral and central components of action of angiotensin on the sympathetic nervous system. J Pharmacol Exp Ther. 1967 Oct;158(1):1–10. [PubMed] [Google Scholar]
- Zimmerman B. G., Gisslen J. Pattern of renal vasoconstriction and transmitter release during sympathetic stimulation in presence of angiotensin and cocaine. J Pharmacol Exp Ther. 1968 Oct;163(2):320–329. [PubMed] [Google Scholar]