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. 1996 Mar;178(5):1347–1350. doi: 10.1128/jb.178.5.1347-1350.1996

Kinetics of pyrimidine(6-4)pyrimidone photoproduct repair in Escherichia coli.

D R Koehler 1, J Courcelle 1, P C Hanawalt 1
PMCID: PMC177809  PMID: 8631712

Abstract

We compared the removal of pyrimidine(6-4)pyrimidone photoproducts [(6-4) photoproducts] and cyclobutane pyrimidine dimers (CPDs) from the genome of repair-proficient Escherichia coli, using monoclonal antibodies specific for each type of lesion. We found that (6-4) photoproducts were removed at a higher rate than CPDs in the first 30 min following a moderate UV dose (40 J/m2). The difference in rates was less than that typically reported for cultured mammalian cells, in which the removal of (6-4) photoproducts is far more rapid than that of CPDs.

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Selected References

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