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. 1986 Dec;61(12):1168–1172. doi: 10.1136/adc.61.12.1168

The medium chain triglyceride diet and intractable epilepsy.

M A Sills, W I Forsythe, D Haidukewych, A MacDonald, M Robinson
PMCID: PMC1778211  PMID: 3101615

Abstract

Fifty children with drug resistant epilepsy were treated with the Medium Chain Triglyceride (MCT) Emulsion diet. Eight achieved complete control of seizures (four without anticonvulsant drugs), and with the addition of anticonvulsants four had seizures reduced in frequency by 90% and 10 by 50-90%. The best results were obtained with astatic myoclonic and absence seizures, but control of seizures was improved in four children with tonic-clonic and three with complex partial seizures. Food given at the same time as MCT helped to reduce side effects, and an extra dose of MCT before bedtime improved control of nocturnal seizures.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Clark B. J., House F. M. Medium chain triglyceride oil ketogenic diets in the treatment of childhood epilepsy. J Hum Nutr. 1978 Apr;32(2):111–116. doi: 10.3109/09637487809144517. [DOI] [PubMed] [Google Scholar]
  2. DeVivo D. C., Pagliara A. S., Prensky A. L. Ketotic hypoglycemia and the ketogenic diet. Neurology. 1973 Jun;23(6):640–649. doi: 10.1212/wnl.23.6.640. [DOI] [PubMed] [Google Scholar]
  3. Dekaban A. S. Plasma lipids in epileptic children treated with the high fat diet. Arch Neurol. 1966 Aug;15(2):177–184. doi: 10.1001/archneur.1966.00470140067009. [DOI] [PubMed] [Google Scholar]
  4. Forsythe W. I., Sills M. A. One drug for childhood grand mal: medical audit for three-year remissions. Dev Med Child Neurol. 1984 Dec;26(6):742–748. doi: 10.1111/j.1469-8749.1984.tb08167.x. [DOI] [PubMed] [Google Scholar]
  5. Gordon N. Medium-chain triglycerides in a ketogenic diet. Dev Med Child Neurol. 1977 Aug;19(4):535–538. doi: 10.1111/j.1469-8749.1977.tb07951.x. [DOI] [PubMed] [Google Scholar]
  6. Hoyt C. S., Billson F. A. Optic neuropathy in ketogenic diet. Br J Ophthalmol. 1979 Mar;63(3):191–194. doi: 10.1136/bjo.63.3.191. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Huttenlocher P. R. Ketonemia and seizures: metabolic and anticonvulsant effects of two ketogenic diets in childhood epilepsy. Pediatr Res. 1976 May;10(5):536–540. doi: 10.1203/00006450-197605000-00006. [DOI] [PubMed] [Google Scholar]
  8. Huttenlocher P. R., Wilbourn A. J., Signore J. M. Medium-chain triglycerides as a therapy for intractable childhood epilepsy. Neurology. 1971 Nov;21(11):1097–1103. doi: 10.1212/wnl.21.11.1097. [DOI] [PubMed] [Google Scholar]
  9. Livingston S. Diagnosis and treatment of childhood myoclonic seizures. Pediatrics. 1974 Apr;53(4):542–548. [PubMed] [Google Scholar]
  10. MILLICHAP J. G., JONES J. D., RUDIS B. P. MECHANISM OF ANTICONVULSANT ACTION OF KETOGENIC DIET. STUDIES IN ANIMALS WITH EXPERIMENTAL SEIZURES AND IN CHILDREN WITH PETIT MAL EPILEPSY. Am J Dis Child. 1964 Jun;107:593–604. [PubMed] [Google Scholar]
  11. Mundy A. R. Artificial urinary sphincters. Arch Dis Child. 1986 Jan;61(1):1–3. doi: 10.1136/adc.61.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]

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