Skip to main content
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1987 Feb;62(2):177–179. doi: 10.1136/adc.62.2.177

Serological study of Pneumocystis carinii infection in the absence of immunosuppression.

M P Gerrard, O B Eden, B Jameson, A W Craft
PMCID: PMC1778238  PMID: 3493735

Abstract

Serum samples from 145 children with no known immunosuppressive illness were examined by indirect immunofluorescence for antibody to Pneumocystis carinii. Positive antibody titres (greater than or equal to 1:8 dilution) were found in 69 children (48%). Antibody could not be detected in the remaining children. Previous studies have shown that at least 75% of children have antibodies to P. carinii by the age of 4 years. This study shows a lower percentage of children with detectable antibody. This may be related to geographical variation of antigen or possibly to the widespread use of co-trimoxazole.

Full text

PDF
177

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Hughes W. T., Kuhn S., Chaudhary S., Feldman S., Verzosa M., Aur R. J., Pratt C., George S. L. Successful chemoprophylaxis for Pneumocystis carinii pneumonitis. N Engl J Med. 1977 Dec 29;297(26):1419–1426. doi: 10.1056/NEJM197712292972602. [DOI] [PubMed] [Google Scholar]
  2. Hughes W. T. Natural mode of acquisition for de novo infection with Pneumocystis carinii. J Infect Dis. 1982 Jun;145(6):842–848. doi: 10.1093/infdis/145.6.842. [DOI] [PubMed] [Google Scholar]
  3. Meuwissen J. H., Tauber I., Leeuwenberg A. D., Beckers P. J., Sieben M. Parasitologic and serologic observations of infection with Pneumocystis in humans. J Infect Dis. 1977 Jul;136(1):43–49. doi: 10.1093/infdis/136.1.43. [DOI] [PubMed] [Google Scholar]
  4. Pifer L. L., Hughes W. T., Stagno S., Woods D. Pneumocystis carinii infection: evidence for high prevalence in normal and immunosuppressed children. Pediatrics. 1978 Jan;61(1):35–41. [PubMed] [Google Scholar]
  5. Price R. A., Hughes W. T. Histopathology of Pneumocystis carinii infestation and infection in malignant disease in childhood. Hum Pathol. 1974 Nov;5(6):737–752. doi: 10.1016/s0046-8177(74)80043-2. [DOI] [PubMed] [Google Scholar]
  6. Shepherd V., Jameson B., Knowles G. K. Pneumocystis carinii pneumonitis: a serological study. J Clin Pathol. 1979 Aug;32(8):773–777. doi: 10.1136/jcp.32.8.773. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Siegel S. E., Nesbit M. E., Baehner R., Sather H., Hammond G. D. Pneumonia during therapy for childhood acute lymphoblastic leukemia. Am J Dis Child. 1980 Jan;134(1):28–34. doi: 10.1001/archpedi.1980.02130130020007. [DOI] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES