Skip to main content
PMC home page
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1987 Feb;62(2):123–127. doi: 10.1136/adc.62.2.123

Remission induced by an elemental diet in small bowel Crohn's disease.

I R Sanderson, S Udeen, P S Davies, M O Savage, J A Walker-Smith
PMCID: PMC1778272  PMID: 3548602

Abstract

Seventeen children with active Crohn's disease of the small intestine were entered into a randomised control trial comparing the efficacy of an elemental diet with that of a high dose steroid regimen. Eight children received an elemental diet (Flexical) through a nasogastric tube for six weeks, followed by reintroduction of food over six weeks during which the Flexical was stopped. Seven children were given intramuscular adrenocorticotrophic hormone followed by oral prednisolone with sulphasalazine. Two children were withdrawn from the trial. The elemental diet was equally effective in inducing an improvement in Lloyd-Still disease activity index, erythrocyte sedimentation rate, C reactive protein and albumin concentrations, and body weight as the high dose steroid regimen. Linear growth, assessed from height velocity over six months, was significantly greater in the children receiving an elemental diet.

Full text

PDF
123

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chong S. K., Bartram C., Campbell C. A., Williams C. B., Blackshaw A. J., Walker-Smith J. A. Chronic inflammatory bowel disease in childhood. Br Med J (Clin Res Ed) 1982 Jan 9;284(6309):101–103. doi: 10.1136/bmj.284.6309.101. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Chong S. K., Blackshaw A. J., Boyle S., Williams C. B., Walker-Smith J. A. Histological diagnosis of chronic inflammatory bowel disease in childhood. Gut. 1985 Jan;26(1):55–59. doi: 10.1136/gut.26.1.55. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Foote K. D., Brocklebank J. T., Meadow S. R. Height attainment in children with steroid-responsive nephrotic syndrome. Lancet. 1985 Oct 26;2(8461):917–919. doi: 10.1016/s0140-6736(85)90851-7. [DOI] [PubMed] [Google Scholar]
  4. Giorgini G. L., Stephens R. V., Thayer W. R., Jr The use of "medical by-pass" in the therapy of Crohn's disease: report of a case. Am J Dig Dis. 1973 Feb;18(2):153–157. doi: 10.1007/BF01073162. [DOI] [PubMed] [Google Scholar]
  5. Gryboski J. D., Spiro H. M. Prognosis in children with Crohn's disease. Gastroenterology. 1978 May;74(5 Pt 1):807–817. [PubMed] [Google Scholar]
  6. Lloyd-Still J. D., Green O. C. A clinical scoring system for chronic inflammatory bowel disease in children. Dig Dis Sci. 1979 Aug;24(8):620–624. doi: 10.1007/BF01333706. [DOI] [PubMed] [Google Scholar]
  7. Morin C. L., Roulet M., Roy C. C., Weber A. Continuous elemental enteral alimentation in children with Crohn's disease and growth failure. Gastroenterology. 1980 Dec;79(6):1205–1210. [PubMed] [Google Scholar]
  8. Morin C. L., Roulet M., Roy C. C., Weber A., Lapointe N. Continuous elemental enteral alimentation in the treatment of children and adolescents with Crohn's disease. JPEN J Parenter Enteral Nutr. 1982 May-Jun;6(3):194–199. doi: 10.1177/0148607182006003194. [DOI] [PubMed] [Google Scholar]
  9. Navarro J., Vargas J., Cezard J. P., Charritat J. L., Polonovski C. Prolonged constant rate elemental enteral nutrition in Crohn's disease. J Pediatr Gastroenterol Nutr. 1982;1(4):541–546. doi: 10.1097/00005176-198212000-00015. [DOI] [PubMed] [Google Scholar]
  10. O'Donoghue D. P., Dawson A. M. Crohn's disease in childhood. Arch Dis Child. 1977 Aug;52(8):627–632. doi: 10.1136/adc.52.8.627. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. O'Moráin C., Segal A. M., Levi A. J., Valman H. B. Elemental diet in acute Crohn's disease. Arch Dis Child. 1983 Jan;58(1):44–47. doi: 10.1136/adc.58.1.44. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. O'Moráin C., Segal A. W., Levi A. J. Elemental diet as primary treatment of acute Crohn's disease: a controlled trial. Br Med J (Clin Res Ed) 1984 Jun 23;288(6434):1859–1862. doi: 10.1136/bmj.288.6434.1859. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Tanner J. M., Whitehouse R. H., Takaishi M. Standards from birth to maturity for height, weight, height velocity, and weight velocity: British children, 1965. II. Arch Dis Child. 1966 Dec;41(220):613–635. doi: 10.1136/adc.41.220.613. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES