Skip to main content
NCBI home page
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1987 Apr;62(4):329–332. doi: 10.1136/adc.62.4.329

Cytomegalovirus infection in day nurseries.

D B Nelson, C S Peckham, K N Pearl, K S Chin, A J Garrett, D E Warren
PMCID: PMC1778342  PMID: 3036017

Abstract

One hundred and seventeen children and 41 teachers in day nurseries were screened for cytomegalovirus (CMV) viruria over a period of one year. Thirty two (27%) children and two (5%) teachers were found to be excreting virus on at least one occasion. Restriction endonuclease typing showed that virus strains isolated from the children were dissimilar, with the exception of those from sibling pairs and one unrelated pair. The virus isolate from one teacher matched those from two unrelated children, while the isolate from another teacher could not be distinguished from that from a sibling pair. The CMV serological state of the 41 teachers was not significantly different from 500 matched controls and no seroconversions occurred. It is concluded that although transmission of CMV among children and teachers may occur in day nurseries, the dissimilarity of most of the virus strains indicates that infection predominantly occurs outside. Furthermore, teachers in day nurseries showed no evidence of an increased risk of past CMV infection when compared with matched controls.

Full text

PDF
329

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adler S. P. The molecular epidemiology of cytomegalovirus transmission among children attending a day care center. J Infect Dis. 1985 Oct;152(4):760–768. doi: 10.1093/infdis/152.4.760. [DOI] [PubMed] [Google Scholar]
  2. Garrett A. J., Warren D. E. A simple technique for endonuclease mapping of cytomegaloviruses. J Virol Methods. 1985 Mar;10(3):187–194. doi: 10.1016/0166-0934(85)90059-x. [DOI] [PubMed] [Google Scholar]
  3. Grillner L., Strangert K. Restriction endonuclease analysis of cytomegalovirus DNA from strains isolated in day care centers. Pediatr Infect Dis. 1986 Mar-Apr;5(2):184–187. doi: 10.1097/00006454-198603000-00004. [DOI] [PubMed] [Google Scholar]
  4. Huang E. S., Kilpatrick B. A., Huang Y. T., Pagano J. S. Detection of human cytomegalovirus and analysis of strain variation. Yale J Biol Med. 1976 Mar;49(1):29–43. [PMC free article] [PubMed] [Google Scholar]
  5. Hutto C., Ricks R., Garvie M., Pass R. F. Epidemiology of cytomegalovirus infections in young children: day care vs. home care. Pediatr Infect Dis. 1985 Mar-Apr;4(2):149–152. doi: 10.1097/00006454-198503000-00008. [DOI] [PubMed] [Google Scholar]
  6. Jones L. A., Duke-Duncan P. M., Yeager A. S. Cytomegaloviral infections in infant-toddler centers: centers for the developmentally delayed versus regular day care. J Infect Dis. 1985 May;151(5):953–955. doi: 10.1093/infdis/151.5.953. [DOI] [PubMed] [Google Scholar]
  7. Pass R. F., August A. M., Dworsky M., Reynolds D. W. Cytomegalovirus infection in day-care center. N Engl J Med. 1982 Aug 19;307(8):477–479. doi: 10.1056/NEJM198208193070804. [DOI] [PubMed] [Google Scholar]
  8. Pass R. F., Hutto S. C., Reynolds D. W., Polhill R. B. Increased frequency of cytomegalovirus infection in children in group day care. Pediatrics. 1984 Jul;74(1):121–126. [PubMed] [Google Scholar]
  9. Peckham C. S., Chin K. S., Coleman J. C., Henderson K., Hurley R., Preece P. M. Cytomegalovirus infection in pregnancy: preliminary findings from a prospective study. Lancet. 1983 Jun 18;1(8338):1352–1355. doi: 10.1016/s0140-6736(83)92138-4. [DOI] [PubMed] [Google Scholar]
  10. Peckham C. S., Garrett A. J., Chin K. S., Preece P. M., Nelson D. B., Warren D. E. Restriction enzyme analysis of cytomegalovirus DNA to study transmission of infection. J Clin Pathol. 1986 Mar;39(3):318–324. doi: 10.1136/jcp.39.3.318. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Stagno S., Reynolds D. W., Pass R. F., Alford C. A. Breast milk and the risk of cytomegalovirus infection. N Engl J Med. 1980 May 8;302(19):1073–1076. doi: 10.1056/NEJM198005083021908. [DOI] [PubMed] [Google Scholar]
  12. Stern H. Isolation of cytomegalovirus and clinical manifestations of infection at different ages. Br Med J. 1968 Mar 16;1(5593):665–669. doi: 10.1136/bmj.1.5593.665. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Weller T. H. The cytomegaloviruses: ubiquitous agents with protean clinical manifestations. II. N Engl J Med. 1971 Jul 29;285(5):267–274. doi: 10.1056/NEJM197107292850507. [DOI] [PubMed] [Google Scholar]
  14. Wilfert C. M., Huang E. S., Stagno S. Restriction endonuclease analysis of cytomegalovirus deoxyribonucleic acid as an epidemiologic tool. Pediatrics. 1982 Nov;70(5):717–721. [PubMed] [Google Scholar]
  15. Yow M. D., Lakeman A. D., Stagno S., Reynolds R. B., Plavidal F. J. Use of restriction enzymes to investigate the source of a primary cytomegalovirus infection in a pediatric nurse. Pediatrics. 1982 Nov;70(5):713–716. [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES