Skip to main content
NCBI home page
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1987 Dec;62(12):1233–1237. doi: 10.1136/adc.62.12.1233

Congenital cytomegalovirus infection: a cause of sensorineural hearing loss.

C S Peckham 1, O Stark 1, J A Dudgeon 1, J A Martin 1, G Hawkins 1
PMCID: PMC1778635  PMID: 2829749

Abstract

Prospective studies have suggested that about 108 children with congenital cytomegalovirus (CMV) infection and bilateral sensorineural hearing loss are born each year in England and Wales; this represents about 12% of all children with congenital sensorineural hearing loss. Over a nine year period 1644 children aged between 6 months and 4 years who were attending the Nuffield Hearing and Speech Centre were screened for CMV infection. The prevalence of CMV in the urine of children with sensorineural hearing loss but no immediate family history of deafness was nearly twice that (13%) found in other children with impaired hearing and those with normal hearing (7%). These findings indicate the importance of CMV as a cause of hearing loss.

Full text

PDF
1233

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Dahle A. J., McCollister F. P., Hamner B. A., Reynolds D. W., Stagno S. Subclinical congenital cytomegalovirus infection and hearing impairment. J Speech Hear Disord. 1974 Aug;39(3):320–329. doi: 10.1044/jshd.3903.320. [DOI] [PubMed] [Google Scholar]
  2. Dahle A. J., McCollister F. P., Stagno S., Reynolds D. W., Hoffman H. E. Progressive hearing impairment in children with congenital cytomegalovirus infection. J Speech Hear Disord. 1979 May;44(2):220–229. doi: 10.1044/jshd.4402.220. [DOI] [PubMed] [Google Scholar]
  3. Davis G. L. In vitro models of viral-induced congenital deafness. Am J Otol. 1981 Oct;3(2):156–160. [PubMed] [Google Scholar]
  4. Davis L. E., Johnsson L. G., Kornfeld M. Cytomegalovirus labyrinthitis in an infant: morphological, virological, and immunofluorescent studies. J Neuropathol Exp Neurol. 1981 Jan;40(1):9–19. [PubMed] [Google Scholar]
  5. Hanshaw J. B., Scheiner A. P., Moxley A. W., Gaev L., Abel V., Scheiner B. School failure and deafness after "silent" congenital cytomegalovirus infection. N Engl J Med. 1976 Aug 26;295(9):468–470. doi: 10.1056/NEJM197608262950902. [DOI] [PubMed] [Google Scholar]
  6. Kumar M. L., Nankervis G. A., Gold E. Inapparent congenital cytomegalovirus infection. A follow-up study. N Engl J Med. 1973 Jun 28;288(26):1370–1372. doi: 10.1056/NEJM197306282882603. [DOI] [PubMed] [Google Scholar]
  7. Kumar M. L., Nankervis G. A., Jacobs I. B., Ernhart C. B., Glasson C. E., McMillan P. M., Gold E. Congenital and postnatally acquired cytomegalovirus infections: long-term follow-up. J Pediatr. 1984 May;104(5):674–679. doi: 10.1016/s0022-3476(84)80942-7. [DOI] [PubMed] [Google Scholar]
  8. MacDonald H., Tobin JO'H Congenital cytomegalovirus infection: a collaborative study on epidemiological, clinical and laboratory findings. Dev Med Child Neurol. 1978 Aug;20(4):471–482. doi: 10.1111/j.1469-8749.1978.tb15248.x. [DOI] [PubMed] [Google Scholar]
  9. McCracken G. H., Jr, Shinefield H. M., Cobb K., Rausen A. R., Dische R., Eichenwald H. F. Congenital cytomegalic inclusion disease. A longitudinal study of 20 patients. Am J Dis Child. 1969 May;117(5):522–539. doi: 10.1001/archpedi.1969.02100030524005. [DOI] [PubMed] [Google Scholar]
  10. Myers E. N., Stool S. Cytomegalic inclusion disease of the inner ear. Laryngoscope. 1968 Nov;78(11):1904–1915. doi: 10.1288/00005537-196811000-00005. [DOI] [PubMed] [Google Scholar]
  11. Pappas D. G. Hearing impairments and vestibular abnormalities among children with subclinical cytomegalovirus. Ann Otol Rhinol Laryngol. 1983 Nov-Dec;92(6 Pt 1):552–557. doi: 10.1177/000348948309200604. [DOI] [PubMed] [Google Scholar]
  12. Pass R. F., Stagno S., Myers G. J., Alford C. A. Outcome of symptomatic congenital cytomegalovirus infection: results of long-term longitudinal follow-up. Pediatrics. 1980 Nov;66(5):758–762. [PubMed] [Google Scholar]
  13. Peckham C. S., Chin K. S., Coleman J. C., Henderson K., Hurley R., Preece P. M. Cytomegalovirus infection in pregnancy: preliminary findings from a prospective study. Lancet. 1983 Jun 18;1(8338):1352–1355. doi: 10.1016/s0140-6736(83)92138-4. [DOI] [PubMed] [Google Scholar]
  14. Peckham C. S., Johnson C., Ades A., Pearl K., Chin K. S. Early acquisition of cytomegalovirus infection. Arch Dis Child. 1987 Aug;62(8):780–785. doi: 10.1136/adc.62.8.780. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Preece P. M., Pearl K. N., Peckham C. S. Congenital cytomegalovirus infection. Arch Dis Child. 1984 Dec;59(12):1120–1126. doi: 10.1136/adc.59.12.1120. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Reynolds D. W., Stagno S., Stubbs K. G., Dahle A. J., Livingston M. M., Saxon S. S., Alford C. A. Inapparent congenital cytomegalovirus infection with elevated cord IgM levels. Casual relation with auditory and mental deficiency. N Engl J Med. 1974 Feb 7;290(6):291–296. doi: 10.1056/NEJM197402072900601. [DOI] [PubMed] [Google Scholar]
  17. Saigal S., Lunyk O., Larke R. P., Chernesky M. A. The outcome in children with congenital cytomegalovirus infection. A longitudinal follow-up study. Am J Dis Child. 1982 Oct;136(10):896–901. doi: 10.1001/archpedi.1982.03970460026006. [DOI] [PubMed] [Google Scholar]
  18. Sheridan M. D. Reported incidence of hearing loss in children of 7 years. Dev Med Child Neurol. 1972 Jun;14(3):296–303. doi: 10.1111/j.1469-8749.1972.tb02593.x. [DOI] [PubMed] [Google Scholar]
  19. Stagno S., Reynolds D. W., Amos C. S., Dahle A. J., McCollister F. P., Mohindra I., Ermocilla R., Alford C. A. Auditory and visual defects resulting from symptomatic and subclinical congenital cytomegaloviral and toxoplasma infections. Pediatrics. 1977 May;59(5):669–678. [PubMed] [Google Scholar]
  20. Stagno S., Reynolds D. W., Pass R. F., Alford C. A. Breast milk and the risk of cytomegalovirus infection. N Engl J Med. 1980 May 8;302(19):1073–1076. doi: 10.1056/NEJM198005083021908. [DOI] [PubMed] [Google Scholar]
  21. Stern H. Cytomegalovirus infection in the neonate and its prevention. Postgrad Med J. 1977 Oct;53(624):588–591. doi: 10.1136/pgmj.53.624.588. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Williamson W. D., Desmond M. M., LaFevers N., Taber L. H., Catlin F. I., Weaver T. G. Symptomatic congenital cytomegalovirus. Disorders of language, learning, and hearing. Am J Dis Child. 1982 Oct;136(10):902–905. doi: 10.1001/archpedi.1982.03970460032007. [DOI] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES