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. 1987 Oct;62(10):997–1000. doi: 10.1136/adc.62.10.997

Hypoxaemia in wheezy infants after bronchodilator treatment.

A Prendiville 1, A Rose 1, D L Maxwell 1, M Silverman 1
PMCID: PMC1778665  PMID: 3118819

Abstract

The response of the bronchi to nebulised salbutamol was measured in five recurrently wheezy infants. Changes in oxygenation (measured by pulse oximeter and transcutaneous PO2 electrodes) and carbon dioxide (measured by transcutaneous PCO2 electrode) were recorded at the same time. Neither nebulised saline nor salbutamol caused any changes in the measurements of airway function. A significant drop in mean oxygen saturation of 2% and of transcutaneous oxygen tension of 1.3 kPa occurred after nebulised salbutamol. No significant change occurred in measurements of transcutaneous carbon dioxide tension, nor was there any significant change in any of these measurements after 2.5 ml of nebulised saline had been given as a control. These results suggest that nebulised salbutamol may cause significant hypoxaemia, in wheezy infants probably by inducing ventilation/perfusion disturbance.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cheriyan G., Helms P., Paky F., Marsden D., Chiu M. C. Transcutaneous estimation of arterial carbon dioxide in intensive care. Which electrode temperature? Arch Dis Child. 1986 Jul;61(7):652–656. doi: 10.1136/adc.61.7.652. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Ferron G. A., Kerrebijn K. F., Weber J. Properties of aerosols produced with three nebulizers. Am Rev Respir Dis. 1976 Nov;114(5):899–908. doi: 10.1164/arrd.1976.114.5.899. [DOI] [PubMed] [Google Scholar]
  3. Lees M. H., Olsen G. D., McGilliard K. L., Newcomb J. D., Sunderland C. O. Chloral hydrate and the carbon dioxide chemoreceptor response: a study of puppies and infants. Pediatrics. 1982 Sep;70(3):447–450. [PubMed] [Google Scholar]
  4. Maayan C., Itzhaki T., Bar-Yishay E., Gross S., Tal A., Godfrey S. The functional response of infants with persistent wheezing to nebulized beclomethasone dipropionate. Pediatr Pulmonol. 1986 Jan-Feb;2(1):9–14. doi: 10.1002/ppul.1950020106. [DOI] [PubMed] [Google Scholar]
  5. Marsden D., Chiu M. C., Paky F., Helms P. Transcutaneous oxygen and carbon dioxide monitoring in intensive care. Arch Dis Child. 1985 Dec;60(12):1158–1161. doi: 10.1136/adc.60.12.1158. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Monaco F., Nickerson B. G., McQuitty J. C. Continuous transcutaneous oxygen and carbon dioxide monitoring in the pediatric ICU. Crit Care Med. 1982 Nov;10(11):765–766. doi: 10.1097/00003246-198211000-00014. [DOI] [PubMed] [Google Scholar]
  7. Murray A. B., Hardwick D. F., Pirie G. E., Fraser B. M. The effects of pressurized isoproterenol and salbutamol in asthmatic children. Pediatrics. 1974 Dec;54(6):746–756. [PubMed] [Google Scholar]
  8. Prendiville A., Green S., Silverman M. Airway responsiveness in wheezy infants: evidence for functional beta adrenergic receptors. Thorax. 1987 Feb;42(2):100–104. doi: 10.1136/thx.42.2.100. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Prendiville A., Green S., Silverman M. Paradoxical response to nebulised salbutamol in wheezy infants, assessed by partial expiratory flow-volume curves. Thorax. 1987 Feb;42(2):86–91. doi: 10.1136/thx.42.2.86. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Radford M. Effect of salbutamol in infants with wheezy bronchitis. Arch Dis Child. 1975 Jul;50(7):535–538. doi: 10.1136/adc.50.7.535. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Roe T. F., Kogut M. D. Idiopathic leucine-sensitive hypoglycemia syndrome: insulin and glucagon responses and effects of diazoxide. Pediatr Res. 1982 Jan;16(1):1–4. doi: 10.1203/00006450-198201001-00001. [DOI] [PubMed] [Google Scholar]
  12. Rutter N., Milner A. D., Hiller E. J. Effect of bronchodilators on respiratory resistance in infants and young children with bronchiolitis and wheezy bronchitis. Arch Dis Child. 1975 Sep;50(9):719–722. doi: 10.1136/adc.50.9.719. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Silverman M., Prendiville A., Green S. Partial expiratory flow-volume curves in infancy: technical aspects. Bull Eur Physiopathol Respir. 1986 May-Jun;22(3):257–262. [PubMed] [Google Scholar]
  14. Stocks J. The functional growth and development of the lung during the first year of life. Early Hum Dev. 1977 Dec;1(3):285–309. doi: 10.1016/0378-3782(77)90041-x. [DOI] [PubMed] [Google Scholar]
  15. Stocks J., Thomson A., Silverman M. The numerical analysis of pressure-flow curves in infancy. Pediatr Pulmonol. 1985 Jan-Feb;1(1):19–26. doi: 10.1002/ppul.1950010107. [DOI] [PubMed] [Google Scholar]
  16. Stokes G. M., Milner A. D., Hodges I. G., Henry R. L., Elphick M. C. Nebulised therapy in acute severe bronchiolitis in infancy. Arch Dis Child. 1983 Apr;58(4):279–282. doi: 10.1136/adc.58.4.279. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Taussig L. M., Landau L. I., Godfrey S., Arad I. Determinants of forced expiratory flows in newborn infants. J Appl Physiol Respir Environ Exerc Physiol. 1982 Nov;53(5):1220–1227. doi: 10.1152/jappl.1982.53.5.1220. [DOI] [PubMed] [Google Scholar]
  18. Thiessen B., Pedersen O. F. A double blind cross-over study of maximal expiratory flows and arterial blood gas tensions in normals, asthmatics and bronchitics after salbutamol and ipratropin. Scand J Respir Dis Suppl. 1979;103:170–177. [PubMed] [Google Scholar]
  19. Wood J. A., Wilson R. S., Bray C. Changes in salbutamol concentration in the reservoir solution of a jet nebulizer. Br J Dis Chest. 1986 Apr;80(2):164–169. doi: 10.1016/0007-0971(86)90037-9. [DOI] [PubMed] [Google Scholar]
  20. Yahav J., Mindorff C., Levison H. The validity of the transcutaneous oxygen tension method in children with cardiorespiratory problems. Am Rev Respir Dis. 1981 Nov;124(5):586–587. doi: 10.1164/arrd.1981.124.5.586. [DOI] [PubMed] [Google Scholar]

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