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. 1988 Oct;63(10):1189–1191. doi: 10.1136/adc.63.10.1189

Randomised controlled trials of phenobarbitone and valproate in febrile convulsions.

R W Newton 1
PMCID: PMC1779011  PMID: 3143313

Abstract

Results from British trials of phenobarbitone and valproate for the prophylactic treatment of febrile convulsions were pooled and analysed on an intention to treat basis. The overall odds ratio for phenobarbitone was 0.8 and for valproate 1.42. Neither result was significant. Neither treatment can be recommended in the light of experience.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bacon C. J., Hierons A. M., Mucklow J. C., Webb J. K., Rawlins M. D., Weightman D. Placebo-controlled study of phenobarbitone and phenytoin in the prophylaxis of febrile convulsions. Lancet. 1981 Sep 19;2(8247):600–604. doi: 10.1016/s0140-6736(81)92742-2. [DOI] [PubMed] [Google Scholar]
  2. Collins R., Yusuf S., Peto R. Overview of randomised trials of diuretics in pregnancy. Br Med J (Clin Res Ed) 1985 Jan 5;290(6461):17–23. doi: 10.1136/bmj.290.6461.17. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Heckmatt J. Z., Houston A. B., Clow D. J., Strephenson J. B., Dodd K. L., Lealman G. T., Logan R. W. Failure of phenobarbitone to prevent febrile convulsions. Br Med J. 1976 Mar 6;1(6009):559–561. doi: 10.1136/bmj.1.6009.559. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Ngwane E., Bower B. Continuous sodium valproate or phenobarbitone in the prevention of 'simple' febrile convulsions. Comparison by a double-blind trial. Arch Dis Child. 1980 Mar;55(3):171–174. doi: 10.1136/adc.55.3.171. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Wallace S. J., Smith J. A. Successful prophylaxis against febrile convulsions with valproic acid or phenobarbitone. Br Med J. 1980 Feb 9;280(6211):353–354. doi: 10.1136/bmj.280.6211.353. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Williams A. J., Evans-Jones L. G., Kindley A. D., Groom P. J. Sodium valproate in the prophylaxis of simple febrile convulsions. Clin Pediatr (Phila) 1979 Jul;18(7):426–430. doi: 10.1177/000992287901800710. [DOI] [PubMed] [Google Scholar]

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