Skip to main content
NCBI home page
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1988 Dec;63(12):1434–1437. doi: 10.1136/adc.63.12.1434

IgG subclass deficiency in asthma.

B G Loftus 1, J F Price 1, A Lobo-Yeo 1, D Vergani 1
PMCID: PMC1779211  PMID: 3232989

Abstract

Total immunoglobulin G (IgG) and subclasses were measured in serum samples from 82 children with chronic asthma, aged 1.5 to 6.3 years, and 76 controls. Concentrations of IgG1, IgG2, IgG3, and total IgG were significantly lower in asthmatic children aged 1 to 5, and IgG2 concentrations were also significantly lower in asthmatic children over 5 years of age. Twenty eight asthmatic children had at least one value in the deficient range, and 26 had IgG2 deficiency alone or in combination. Five children had IgG2 and IgA deficiency. These 28 children were significantly younger and fewer had raised IgE concentrations than the remainder. IgG subclass deficiency, which may reflect delayed maturation of the immune system, is common in young asthmatic children, and may have a role in the pathogenesis of the disease.

Full text

PDF
1434

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Berger W., Pollock J., Kiechel F., Dunning M., Pearlman D. S. Immunoglobulin levels in children with chronic severe asthma. Ann Allergy. 1978 Aug;41(2):67–74. [PubMed] [Google Scholar]
  2. Buckley R. H., Dees S. C., O'Fallon W. M. Serum immunoglobulins. I. Levels in normal children and in uncomplicated childhood allergy. Pediatrics. 1968 Mar;41(3):600–611. [PubMed] [Google Scholar]
  3. Empey D. W., Laitinen L. A., Jacobs L., Gold W. M., Nadel J. A. Mechanisms of bronchial hyperreactivity in normal subjects after upper respiratory tract infection. Am Rev Respir Dis. 1976 Feb;113(2):131–139. doi: 10.1164/arrd.1976.113.2.131. [DOI] [PubMed] [Google Scholar]
  4. Richardson V. F., Larcher V. F., Price J. F. A common congenital immunodeficiency predisposing to infection and atopy in infancy. Arch Dis Child. 1983 Oct;58(10):799–802. doi: 10.1136/adc.58.10.799. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Shackelford P. G., Granoff D. M., Nahm M. H., Scott M. G., Suarez B., Pandey J. P., Nelson S. J. Relation of age, race, and allotype to immunoglobulin subclass concentrations. Pediatr Res. 1985 Aug;19(8):846–849. doi: 10.1203/00006450-198508000-00014. [DOI] [PubMed] [Google Scholar]
  6. Siber G. R., Schur P. H., Aisenberg A. C., Weitzman S. A., Schiffman G. Correlation between serum IgG-2 concentrations and the antibody response to bacterial polysaccharide antigens. N Engl J Med. 1980 Jul 24;303(4):178–182. doi: 10.1056/NEJM198007243030402. [DOI] [PubMed] [Google Scholar]
  7. Smith J. M. Skin tests and atopic allergy in children. Clin Allergy. 1973 Sep;3(3):269–275. doi: 10.1111/j.1365-2222.1973.tb01333.x. [DOI] [PubMed] [Google Scholar]
  8. Smith T. F., Morris E. C., Bain R. P. IgG subclasses in nonallergic children with chronic chest symptoms. J Pediatr. 1984 Dec;105(6):896–900. doi: 10.1016/s0022-3476(84)80073-6. [DOI] [PubMed] [Google Scholar]
  9. Soothill J. F. President's address. Some intrinsic and extrinsic factors predisposing to allergy. Proc R Soc Med. 1976 Jun;69(6):439–442. doi: 10.1177/003591577606900617. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Taylor B., Norman A. P., Orgel H. A., Stokes C. R., Turner M. W., Soothill J. F. Transient IgA deficiency and pathogenesis of infantile atopy. Lancet. 1973 Jul 21;2(7821):111–113. doi: 10.1016/s0140-6736(73)93060-2. [DOI] [PubMed] [Google Scholar]
  11. Turner M. W., Mowbray J. F., Harvey B. A., Brostoff J., Wells R. S., Soothill J. F. Defective yeast opsonization and C2 deficiency in atopic patients. Clin Exp Immunol. 1978 Nov;34(2):253–259. [PMC free article] [PubMed] [Google Scholar]
  12. Umetsu D. T., Ambrosino D. M., Quinti I., Siber G. R., Geha R. S. Recurrent sinopulmonary infection and impaired antibody response to bacterial capsular polysaccharide antigen in children with selective IgG-subclass deficiency. N Engl J Med. 1985 Nov 14;313(20):1247–1251. doi: 10.1056/NEJM198511143132002. [DOI] [PubMed] [Google Scholar]
  13. Walker L., Johnson G. D., MacLennan I. C. The IgG subclass responses of human lymphocytes to B-cell activators. Immunology. 1983 Oct;50(2):269–272. [PMC free article] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES