Abstract
The aim of the present study is to determine whether patients with primary spontaneous pneumothorax (PSP) are subject to oxidative stress. For this purpose, we measured the activities of red blood cell superoxide dismutase, which is an antioxidant enzyme, and the level of plasma malondialdehyde, which is one of the lipid peroxidation markers, in a group of patients with PSP. The study was carried out with 16 patients with PSP and 24 healthy individuals. The two groups were similar to each other in terms of sex, age and smoking attitudes. Erythrocyte superoxide dismutase activity was found to be significantly lower in patients with PSP than in the control group (p < 0.01). The plasma malondialdehyde levels were significantly high in patients with PSP (p < 0.01). Our results suggest that oxidative stress may contribute to the pathogenesis of PSP.
Full Text
The Full Text of this article is available as a PDF (56.6 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Halliwell B. Oxidative stress, nutrition and health. Experimental strategies for optimization of nutritional antioxidant intake in humans. Free Radic Res. 1996 Jul;25(1):57–74. doi: 10.3109/10715769609145656. [DOI] [PubMed] [Google Scholar]
- Halvorsen S. M., Dull W. L. Phenazopyridine-induced sulfhemoglobinemia: inadvertent rechallenge. Am J Med. 1991 Sep;91(3):315–317. doi: 10.1016/0002-9343(91)90135-k. [DOI] [PubMed] [Google Scholar]
- Janoff A. Elastases and emphysema. Current assessment of the protease-antiprotease hypothesis. Am Rev Respir Dis. 1985 Aug;132(2):417–433. doi: 10.1164/arrd.1985.132.2.417. [DOI] [PubMed] [Google Scholar]
- Loeper J., Goy J., Rozensztajn L., Bedu O., Moisson P. Lipid peroxidation and protective enzymes during myocardial infarction. Clin Chim Acta. 1991 Feb 15;196(2-3):119–125. doi: 10.1016/0009-8981(91)90064-j. [DOI] [PubMed] [Google Scholar]
- Ohkawa H., Ohishi N., Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979 Jun;95(2):351–358. doi: 10.1016/0003-2697(79)90738-3. [DOI] [PubMed] [Google Scholar]
- Sharpe I. K., Ahmad M., Braun W. Familial spontaneous pneumothorax and HLA antigens. Chest. 1980 Aug;78(2):264–268. doi: 10.1378/chest.78.2.264. [DOI] [PubMed] [Google Scholar]