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. 2004 Dec;13(5-6):321–325. doi: 10.1155/S096293510400047X

Leptin levels in obese women with and without type 2 diabetes mellitus.

Mehmet Akif Buyukbese 1, Ali Cetinkaya 1, Ramazan Kocabas 1, Aytekin Guven 1, Mehmet Tarakcioglu 1
PMCID: PMC1781572  PMID: 15770047

Abstract

INTRODUCTION: The role of leptin has been more clear in the endocrinology area after the discovery of its secretion from the adipose tissue. The aim of the study is to investigate the leptin levels in obese women in whom type 2 diabetes mellitus were present or absent. MATERIALS AND METHODS: Thirty-five obese women with type 2 diabetes mellitus (group 1) and 34 obese women without type 2 diabetes mellitus (group 2) were enrolled in the study. In both groups the body mass index (BMI), waist circumference, and waist-to-hip ratio were measured. Leptin, HbA1c, creatinine and the lipid profile were assessed. RESULTS: Leptin was found to be statistically significantly lower in group 1 than in group 2 (40.22 +/- 17.77 ng/ml versus 50.12 +/- 15.51 ng/ml, respectively; p = 0.019). It was well correlated with BMI in group 1 (r = 0.60, p = 0.0001). In group 1 also, correlation of leptin was moderate with creatinine and high-density lipoprotein-cholesterol (r = 0.36, p = 0.037 versus r = 0.37, p = 0.027, respectively), whereas triglyceride had a negative correlation (r = -0.34, p = 0.046). In group 2, the only significant correlation with leptin was BMI (r = 0.41, p = 0.02). Leptin was also significantly lower in 17 subjects with poorly controlled diabetes mellitus than in 18 well-controlled diabetics (33.54 +/- 15.82 ng/ml versus 44.61 +/- 17.54 ng/ml, respectively; p = 0.038). CONCLUSION: Since leptin is lower in obese women with diabetes than without diabetes and additionally it is even lower in the poorly controlled diabetes subgroup, we think that further studies a rerequired to make clear the issue for lower leptin levels, whether it is a reason or an outcome.

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Selected References

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  1. Aguilera Abelardo, Bajo M. Auxiliadora, Rebollo Francisco, Díez Juan J., Díaz Candido, Paiva Ana, Codoceo Rosa, Selgas Rafael. Leptin as a marker of nutrition and cardiovascular risk in peritoneal dialysis patients. Adv Perit Dial. 2002;18:212–217. [PubMed] [Google Scholar]
  2. Barbier Maryse, Vidal Hubert, Desreumaux Pierre, Dubuquoy Laurent, Bourreille Arnaud, Colombel Jean-François, Cherbut Christine, Galmiche Jean-Paul. Overexpression of leptin mRNA in mesenteric adipose tissue in inflammatory bowel diseases. Gastroenterol Clin Biol. 2003 Nov;27(11):987–991. [PubMed] [Google Scholar]
  3. Bedir Abdulkerim, Topbas Murat, Tanyeri Fulya, Alvur Muhlise, Arik Nurol. Leptin might be a regulator of serum uric acid concentrations in humans. Jpn Heart J. 2003 Jul;44(4):527–536. doi: 10.1536/jhj.44.527. [DOI] [PubMed] [Google Scholar]
  4. Bertin E., Rich N., Schneider N., Larbre H., Marcus C., Durlach V., Leutenegger M. Insulin and body fat distribution have no direct effect on plasma leptin levels in obese Caucasian women with and without type 2 diabetes mellitus. Diabetes Metab. 1998 Jun;24(3):229–234. [PubMed] [Google Scholar]
  5. Ceddia R. B., William W. N., Jr, Carpinelli A. R., Curi R. Modulation of insulin secretion by leptin. Gen Pharmacol. 1999 Feb;32(2):233–237. doi: 10.1016/s0306-3623(98)00185-2. [DOI] [PubMed] [Google Scholar]
  6. Chen K. W., Boyko E. J., Bergstrom R. W., Leonetti D. L., Newell-Morris L., Wahl P. W., Fujimoto W. Y. Earlier appearance of impaired insulin secretion than of visceral adiposity in the pathogenesis of NIDDM. 5-Year follow-up of initially nondiabetic Japanese-American men. Diabetes Care. 1995 Jun;18(6):747–753. doi: 10.2337/diacare.18.6.747. [DOI] [PubMed] [Google Scholar]
  7. Clément K., Lahlou N., Ruiz J., Hager J., Bougnères P., Basdevant A., Guy-Grand B., Froguel P. Association of poorly controlled diabetes with low serum leptin in morbid obesity. Int J Obes Relat Metab Disord. 1997 Jul;21(7):556–561. doi: 10.1038/sj.ijo.0800440. [DOI] [PubMed] [Google Scholar]
  8. Considine R. V., Sinha M. K., Heiman M. L., Kriauciunas A., Stephens T. W., Nyce M. R., Ohannesian J. P., Marco C. C., McKee L. J., Bauer T. L. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med. 1996 Feb 1;334(5):292–295. doi: 10.1056/NEJM199602013340503. [DOI] [PubMed] [Google Scholar]
  9. Correia Marcelo Lima de Gusmao, Haynes William Geoffrey. Leptin, obesity and cardiovascular disease. Curr Opin Nephrol Hypertens. 2004 Mar;13(2):215–223. doi: 10.1097/00041552-200403000-00010. [DOI] [PubMed] [Google Scholar]
  10. Donahue R. P., Prineas R. J., Donahue R. D., Zimmet P., Bean J. A., De Courten M., Collier G., Goldberg R. B., Skyler J. S., Schneiderman N. Is fasting leptin associated with insulin resistance among nondiabetic individuals? The Miami Community Health Study. Diabetes Care. 1999 Jul;22(7):1092–1096. doi: 10.2337/diacare.22.7.1092. [DOI] [PubMed] [Google Scholar]
  11. Everhart J. E., Pettitt D. J., Bennett P. H., Knowler W. C. Duration of obesity increases the incidence of NIDDM. Diabetes. 1992 Feb;41(2):235–240. doi: 10.2337/diab.41.2.235. [DOI] [PubMed] [Google Scholar]
  12. Frederich R. C., Hamann A., Anderson S., Löllmann B., Lowell B. B., Flier J. S. Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat Med. 1995 Dec;1(12):1311–1314. doi: 10.1038/nm1295-1311. [DOI] [PubMed] [Google Scholar]
  13. Friedewald W. T., Levy R. I., Fredrickson D. S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972 Jun;18(6):499–502. [PubMed] [Google Scholar]
  14. Goren Itamar, Kämpfer Heiko, Podda Maurizio, Pfeilschifter Josef, Frank Stefan. Leptin and wound inflammation in diabetic ob/ob mice: differential regulation of neutrophil and macrophage influx and a potential role for the scab as a sink for inflammatory cells and mediators. Diabetes. 2003 Nov;52(11):2821–2832. doi: 10.2337/diabetes.52.11.2821. [DOI] [PubMed] [Google Scholar]
  15. Gómez-Ambrosi Javier, Salvador Javier, Páramo Jose A., Orbe Josune, de Irala Jokin, Diez-Caballero Alberto, Gil María J., Cienfuegos Javier A., Frühbeck Gema. Involvement of leptin in the association between percentage of body fat and cardiovascular risk factors. Clin Biochem. 2002 Jun;35(4):315–320. doi: 10.1016/s0009-9120(02)00320-x. [DOI] [PubMed] [Google Scholar]
  16. Haluzík M., Matoulek M., Svacina S., Hilgertová J., Haas T. The influence of short-term fasting on serum leptin levels, and selected hormonal and metabolic parameters in morbidly obese and lean females. Endocr Res. 2001 Feb-May;27(1-2):251–260. doi: 10.1081/erc-100107185. [DOI] [PubMed] [Google Scholar]
  17. Hodge A. M., Boyko E. J., de Courten M., Zimmet P. Z., Chitson P., Tuomilehto J., Alberti K. G. Leptin and other components of the Metabolic Syndrome in Mauritius--a factor analysis. Int J Obes Relat Metab Disord. 2001 Jan;25(1):126–131. doi: 10.1038/sj.ijo.0801522. [DOI] [PubMed] [Google Scholar]
  18. Jockenhövel F., Blum W. F., Vogel E., Englaro P., Müller-Wieland D., Reinwein D., Rascher W., Krone W. Testosterone substitution normalizes elevated serum leptin levels in hypogonadal men. J Clin Endocrinol Metab. 1997 Aug;82(8):2510–2513. doi: 10.1210/jcem.82.8.4174. [DOI] [PubMed] [Google Scholar]
  19. Johannsson G., Karlsson C., Lönn L., Mårin P., Björntorp P., Sjöström L., Carlsson B., Carlsson L. M., Bengtsson B. A. Serum leptin concentration and insulin sensitivity in men with abdominal obesity. Obes Res. 1998 Nov;6(6):416–421. doi: 10.1002/j.1550-8528.1998.tb00373.x. [DOI] [PubMed] [Google Scholar]
  20. Kieffer T. J., Heller R. S., Leech C. A., Holz G. G., Habener J. F. Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic beta-cells. Diabetes. 1997 Jun;46(6):1087–1093. doi: 10.2337/diab.46.6.1087. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. La Cava Antonio, Alviggi Carlo, Matarese Giuseppe. Unraveling the multiple roles of leptin in inflammation and autoimmunity. J Mol Med (Berl) 2003 Oct 10;82(1):4–11. doi: 10.1007/s00109-003-0492-1. [DOI] [PubMed] [Google Scholar]
  22. La Cava Antonio, Matarese Giuseppe, Ebling Fanny M., Hahn Bevra H. Leptin-based immune intervention: current status and future directions. Curr Opin Investig Drugs. 2003 Nov;4(11):1327–1332. [PubMed] [Google Scholar]
  23. Liuzzi A., Savia G., Tagliaferri M., Lucantoni R., Berselli M. E., Petroni M. L., De Medici C., Viberti G. C. Serum leptin concentration in moderate and severe obesity: relationship with clinical, anthropometric and metabolic factors. Int J Obes Relat Metab Disord. 1999 Oct;23(10):1066–1073. doi: 10.1038/sj.ijo.0801036. [DOI] [PubMed] [Google Scholar]
  24. Mohamed-Ali V., Pinkney J. H., Coppack S. W. Adipose tissue as an endocrine and paracrine organ. Int J Obes Relat Metab Disord. 1998 Dec;22(12):1145–1158. doi: 10.1038/sj.ijo.0800770. [DOI] [PubMed] [Google Scholar]
  25. Muoio Deborah M., Lynis Dohm G. Peripheral metabolic actions of leptin. Best Pract Res Clin Endocrinol Metab. 2002 Dec;16(4):653–666. doi: 10.1053/beem.2002.0223. [DOI] [PubMed] [Google Scholar]
  26. Nagy T. R., Gower B. A. Correlates of leptin concentration in the San Antonio Heart Study. Ann Epidemiol. 1997 Feb;7(2):79–80. doi: 10.1016/s1047-2797(97)00001-x. [DOI] [PubMed] [Google Scholar]
  27. Pelleymounter M. A., Cullen M. J., Baker M. B., Hecht R., Winters D., Boone T., Collins F. Effects of the obese gene product on body weight regulation in ob/ob mice. Science. 1995 Jul 28;269(5223):540–543. doi: 10.1126/science.7624776. [DOI] [PubMed] [Google Scholar]
  28. Prins Johannes B. Adipose tissue as an endocrine organ. Best Pract Res Clin Endocrinol Metab. 2002 Dec;16(4):639–651. doi: 10.1053/beem.2002.0222. [DOI] [PubMed] [Google Scholar]
  29. Radaelli Tatjana, Varastehpour Ali, Catalano Patrick, Hauguel-de Mouzon Sylvie. Gestational diabetes induces placental genes for chronic stress and inflammatory pathways. Diabetes. 2003 Dec;52(12):2951–2958. doi: 10.2337/diabetes.52.12.2951. [DOI] [PubMed] [Google Scholar]
  30. Rossetti L., Massillon D., Barzilai N., Vuguin P., Chen W., Hawkins M., Wu J., Wang J. Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action. J Biol Chem. 1997 Oct 31;272(44):27758–27763. doi: 10.1074/jbc.272.44.27758. [DOI] [PubMed] [Google Scholar]
  31. Satman Ilhan, Yilmaz Temel, Sengül Ahmet, Salman Serpil, Salman Fatih, Uygur Sevil, Bastar Irfan, Tütüncü Yildiz, Sargin Mehmet, Dinçag Nevin. Population-based study of diabetes and risk characteristics in Turkey: results of the turkish diabetes epidemiology study (TURDEP). Diabetes Care. 2002 Sep;25(9):1551–1556. doi: 10.2337/diacare.25.9.1551. [DOI] [PubMed] [Google Scholar]
  32. Shamsuzzaman Abu S. M., Winnicki Mikolaj, Wolk Robert, Svatikova Anna, Phillips Bradley G., Davison Diane E., Berger Peter B., Somers Virend K. Independent association between plasma leptin and C-reactive protein in healthy humans. Circulation. 2004 Apr 26;109(18):2181–2185. doi: 10.1161/01.CIR.0000127960.28627.75. [DOI] [PubMed] [Google Scholar]
  33. Siddiqui Arif Rasheed, Abbas Zaigham Ali. Leptin and liver disease: facts and presumptions. J Coll Physicians Surg Pak. 2004 Feb;14(2):122–124. [PubMed] [Google Scholar]
  34. Sitaraman Shanthi, Liu Xia, Charrier Laetitia, Gu Li Hao, Ziegler Thomas R., Gewirtz Andrew, Merlin Didier. Colonic leptin: source of a novel proinflammatory cytokine involved in IBD. FASEB J. 2004 Feb 20;18(6):696–698. doi: 10.1096/fj.03-0422fje. [DOI] [PubMed] [Google Scholar]
  35. Sivitz William I., Wayson Sheila M., Bayless Margaret L., Larson Linda F., Sinkey Christine, Bar Robert S., Haynes William G. Leptin and body fat in type 2 diabetes and monodrug therapy. J Clin Endocrinol Metab. 2003 Apr;88(4):1543–1553. doi: 10.1210/jc.2002-021193. [DOI] [PubMed] [Google Scholar]
  36. Stejskal David, Adamovská Sylva, Bartek Josef, Juráková Renata, Prosková Jitka. Resistin - concentrations in persons with type 2 diabetes mellitus and in individuals with acute inflammatory disease. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2003 Nov;147(1):63–69. [PubMed] [Google Scholar]
  37. Sweeney Gary. Leptin signalling. Cell Signal. 2002 Aug;14(8):655–663. doi: 10.1016/s0898-6568(02)00006-2. [DOI] [PubMed] [Google Scholar]
  38. Tasaka Y., Yanagisawa K., Iwamoto Y. Human plasma leptin in obese subjects and diabetics. Endocr J. 1997 Oct;44(5):671–676. doi: 10.1507/endocrj.44.671. [DOI] [PubMed] [Google Scholar]
  39. Tuzun Ahmet, Uygun Ahmet, Yesilova Zeki, Ozel A. Melih, Erdil Ahmet, Yaman Halil, Bagci Sait, Gulsen Mustafa, Karaeren Necmettin, Dagalp Kemal. Leptin levels in the acute stage of ulcerative colitis. J Gastroenterol Hepatol. 2004 Apr;19(4):429–432. doi: 10.1111/j.1440-1746.2003.03300.x. [DOI] [PubMed] [Google Scholar]
  40. Vettor R., De Pergola G., Pagano C., Englaro P., Laudadio E., Giorgino F., Blum W. F., Giorgino R., Federspil G. Gender differences in serum leptin in obese people: relationships with testosterone, body fat distribution and insulin sensitivity. Eur J Clin Invest. 1997 Dec;27(12):1016–1024. doi: 10.1046/j.1365-2362.1997.2270773.x. [DOI] [PubMed] [Google Scholar]
  41. Vidal H. Obésité et inflammation: les adipocytokines. Ann Endocrinol (Paris) 2003 Nov;64(5 Pt 2):S40–S44. [PubMed] [Google Scholar]
  42. de Courten M., Zimmet P., Hodge A., Collins V., Nicolson M., Staten M., Dowse G., Alberti K. G. Hyperleptinaemia: the missing link in the, metabolic syndrome? Diabet Med. 1997 Mar;14(3):200–208. doi: 10.1002/(SICI)1096-9136(199703)14:3<200::AID-DIA336>3.0.CO;2-V. [DOI] [PubMed] [Google Scholar]

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