Abstract
Benign prostate hypertrophy (BPH) is the most common benign tumor in men due to obstruction of the urethra and, finally, uremia. Malondialdehyde (MDA) is a product derived from peroxidation of polyunsaturated fatty acids and related esters. Evaluation of MDA in serum represents a non-invasive biomarker of oxidative stress. Prostate-specific antigen (PSA) is a sensitive marker for prostatic hypertrophy and cancer. We analyzed MDA serum levels to evaluate the oxidative stress in BPH. To this end, 22 BPH patients and 22 healthy donors were enrolled. Data show an increase of MDA level in BPH patients and a positive correlation between PSA and MDA levels. In conclusion, we describe a previously unknown relationship between PSA and MDA as an index of inflammation and oxidative stress in BPH.
Full Text
The Full Text of this article is available as a PDF (61.0 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Meagher E. A., FitzGerald G. A. Indices of lipid peroxidation in vivo: strengths and limitations. Free Radic Biol Med. 2000 Jun 15;28(12):1745–1750. doi: 10.1016/s0891-5849(00)00232-x. [DOI] [PubMed] [Google Scholar]
- Muradian K., Schachtschabel D. O. The role of apoptosis in aging and age-related disease: update. Z Gerontol Geriatr. 2001 Dec;34(6):441–446. doi: 10.1007/s003910170015. [DOI] [PubMed] [Google Scholar]
- Teillac P., Peyret C., Leroy M., Najean Y., Le Duc A. L'antigène spécifique de la prostate en pathologie prostatique. Ann Urol (Paris) 1988;22(3):193–196. [PubMed] [Google Scholar]
- Wick G., Jansen-Dürr P., Berger P., Blasko I., Grubeck-Loebenstein B. Diseases of aging. Vaccine. 2000 Feb 25;18(16):1567–1583. doi: 10.1016/s0264-410x(99)00489-2. [DOI] [PubMed] [Google Scholar]