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. 2003 Dec;12(6):361–365. doi: 10.1080/09629350310001633360

Levels of serum IL-1beta, IL-2, IL-8 and tumor necrosis factor-alpha in patients with unstable angina pectoris.

Ali Ozeren 1, Mustafa Aydin 1, Mehmet Tokac 1, Nejat Demircan 1, Murat Unalacak 1, Ahmet Gurel 1, Mehmet Yazici 1
PMCID: PMC1781634  PMID: 14668096

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Selected References

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  1. Caligiuri G., Paulsson G., Nicoletti A., Maseri A., Hansson G. K. Evidence for antigen-driven T-cell response in unstable angina. Circulation. 2000 Sep 5;102(10):1114–1119. doi: 10.1161/01.cir.102.10.1114. [DOI] [PubMed] [Google Scholar]
  2. Danielsen R., Onundarson P. T., Thors H., Vidarsson B., Morrissey J. H. Activated and total coagulation factor VII, and fibrinogen in coronary artery disease. Scand Cardiovasc J. 1998;32(2):87–95. doi: 10.1080/14017439850140238. [DOI] [PubMed] [Google Scholar]
  3. Ernst E., Koenig W. Fibrinogen and cardiovascular risk. Vasc Med. 1997;2(2):115–125. doi: 10.1177/1358863X9700200207. [DOI] [PubMed] [Google Scholar]
  4. Galea J., Armstrong J., Gadsdon P., Holden H., Francis S. E., Holt C. M. Interleukin-1 beta in coronary arteries of patients with ischemic heart disease. Arterioscler Thromb Vasc Biol. 1996 Aug;16(8):1000–1006. doi: 10.1161/01.atv.16.8.1000. [DOI] [PubMed] [Google Scholar]
  5. Hillis G. S., Flapan A. D. Cell adhesion molecules in cardiovascular disease: a clinical perspective. Heart. 1998 May;79(5):429–431. doi: 10.1136/hrt.79.5.429. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Ho C. H., Wang S. P., Jap T. S. Hemostatic risk factors of coronary artery disease in the Chinese. Int J Cardiol. 1995 Aug;51(1):79–84. doi: 10.1016/0167-5273(95)02365-4. [DOI] [PubMed] [Google Scholar]
  7. Koenig W. Haemostatic risk factors for cardiovascular diseases. Eur Heart J. 1998 Apr;19 (Suppl 100):C39–C43. [PubMed] [Google Scholar]
  8. Koukkunen H., Penttilä K., Kemppainen A., Halinen M., Penttila I., Rantanen T., Pyörälä K. C-reactive protein, fibrinogen, interleukin-6 and tumour necrosis factor-alpha in the prognostic classification of unstable angina pectoris. Ann Med. 2001 Feb;33(1):37–47. doi: 10.3109/07853890109002058. [DOI] [PubMed] [Google Scholar]
  9. Li D., Zhao L., Liu M., Du X., Ding W., Zhang J., Mehta J. L. Kinetics of tumor necrosis factor alpha in plasma and the cardioprotective effect of a monoclonal antibody to tumor necrosis factor alpha in acute myocardial infarction. Am Heart J. 1999 Jun;137(6):1145–1152. doi: 10.1016/s0002-8703(99)70375-3. [DOI] [PubMed] [Google Scholar]
  10. Liuzzo G., Goronzy J. J., Yang H., Kopecky S. L., Holmes D. R., Frye R. L., Weyand C. M. Monoclonal T-cell proliferation and plaque instability in acute coronary syndromes. Circulation. 2000 Jun 27;101(25):2883–2888. doi: 10.1161/01.cir.101.25.2883. [DOI] [PubMed] [Google Scholar]
  11. Miya Y., Kanda T., Tamura J., Sumino H., Kurabayashi M. A new murine model of coronary artery thrombosis and role of interleukin-8 in the development of coronary thrombosis. Res Commun Mol Pathol Pharmacol. 2000 Jul-Aug;108(1-2):108–115. [PubMed] [Google Scholar]
  12. Mizia-Stec Katarzyna, Mandecki Tadeusz, Zahorska-Markiewicz Barbara, Janowska Joanna, Szulc Andrzej, Jastrzebska-Maj Ewa, Szymanski Leszek, Majewski Tomasz. Selected cytokines and soluble forms of cytokine receptors in coronary artery disease. Eur J Intern Med. 2002 Mar;13(2):115–122. doi: 10.1016/s0953-6205(02)00004-3. [DOI] [PubMed] [Google Scholar]
  13. Mulvihill N., Foley J. B., Ghaisas N., Murphy R., Crean P., Walsh M. Early temporal expression of soluble cellular adhesion molecules in patients with unstable angina and subendocardial myocardial infarction. Am J Cardiol. 1999 Apr 15;83(8):1265-7, A9. doi: 10.1016/s0002-9149(99)00070-3. [DOI] [PubMed] [Google Scholar]
  14. Neri Serneri G. G., Prisco D., Martini F., Gori A. M., Brunelli T., Poggesi L., Rostagno C., Gensini G. F., Abbate R. Acute T-cell activation is detectable in unstable angina. Circulation. 1997 Apr 1;95(7):1806–1812. doi: 10.1161/01.cir.95.7.1806. [DOI] [PubMed] [Google Scholar]
  15. Oemar B. S. Is interleukin-1 beta a triggering factor for restenosis? Cardiovasc Res. 1999 Oct;44(1):17–19. doi: 10.1016/s0008-6363(99)00215-1. [DOI] [PubMed] [Google Scholar]
  16. Price D. T., Loscalzo J. Cellular adhesion molecules and atherogenesis. Am J Med. 1999 Jul;107(1):85–97. doi: 10.1016/s0002-9343(99)00153-9. [DOI] [PubMed] [Google Scholar]
  17. Qi Xiaoyong, Peng Yingxin, Gu Jian, Li Shuren, Zheng Shiling, Zhang Jianqing, Wang Tianhong. Inflammatory cytokine release in patients with unstable angina after coronary angioplasty. Jpn Heart J. 2002 Mar;43(2):103–115. doi: 10.1536/jhj.43.103. [DOI] [PubMed] [Google Scholar]
  18. Ross R. Atherosclerosis is an inflammatory disease. Am Heart J. 1999 Nov;138(5 Pt 2):S419–S420. doi: 10.1016/s0002-8703(99)70266-8. [DOI] [PubMed] [Google Scholar]
  19. Simiti A., Vida-Simiti L., Cristea A., Olinic N. Increased plasma levels of interleukin-8 in patients with unstable angina pectoris. Rom J Intern Med. 1998 Jan-Jun;36(1-2):47–56. [PubMed] [Google Scholar]
  20. Simon A. D., Yazdani S., Wang W., Schwartz A., Rabbani L. E. Circulating levels of IL-1beta, a prothrombotic cytokine, are elevated in unstable angina versus stable angina. J Thromb Thrombolysis. 2000 Apr;9(3):217–222. doi: 10.1023/a:1018758409934. [DOI] [PubMed] [Google Scholar]
  21. Simon A. D., Yazdani S., Wang W., Schwartz A., Rabbani L. E. Elevated plasma levels of interleukin-2 and soluble IL-2 receptor in ischemic heart disease. Clin Cardiol. 2001 Mar;24(3):253–256. doi: 10.1002/clc.4960240315. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Takeshita S., Isshiki T., Ochiai M., Ishikawa T., Nishiyama Y., Fusano T., Toyoizumi H., Kondo K., Ono Y., Sato T. Systemic inflammatory responses in acute coronary syndrome: increased activity observed in polymorphonuclear leukocytes but not T lymphocytes. Atherosclerosis. 1997 Dec;135(2):187–192. doi: 10.1016/s0021-9150(97)00160-3. [DOI] [PubMed] [Google Scholar]
  23. Weissberg P. Mechanisms modifying atherosclerotic disease - from lipids to vascular biology. Atherosclerosis. 1999 Sep 9;147 (Suppl 1):S3–10. doi: 10.1016/s0021-9150(99)00249-x. [DOI] [PubMed] [Google Scholar]
  24. Worthley S. G., Osende J. I., Helft G., Badimon J. J., Fuster V. Coronary artery disease: pathogenesis and acute coronary syndromes. Mt Sinai J Med. 2001 May;68(3):167–181. [PubMed] [Google Scholar]
  25. Zhou R. H., Shi Q., Gao H. Q., Shen B. J. Changes in serum interleukin-8 and interleukin-12 levels in patients with ischemic heart disease in a Chinese population. J Atheroscler Thromb. 2001;8(1):30–32. doi: 10.5551/jat1994.8.30. [DOI] [PubMed] [Google Scholar]
  26. van Willigen G., Gorter G., Akkerman J. W. LDLs increase the exposure of fibrinogen binding sites on platelets and secretion of dense granules. Arterioscler Thromb. 1994 Jan;14(1):41–46. doi: 10.1161/01.atv.14.1.41. [DOI] [PubMed] [Google Scholar]

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