Skip to main content
Mediators of Inflammation logoLink to Mediators of Inflammation
. 2001 Dec;10(6):304–305. doi: 10.1080/09629350152700975

Asthma, atopy, antibiotics and the bowel.

J Crane 1
PMCID: PMC1781721  PMID: 11817669

Full Text

The Full Text of this article is available as a PDF (75.7 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alm J. S., Swartz J., Lilja G., Scheynius A., Pershagen G. Atopy in children of families with an anthroposophic lifestyle. Lancet. 1999 May 1;353(9163):1485–1488. doi: 10.1016/S0140-6736(98)09344-1. [DOI] [PubMed] [Google Scholar]
  2. Arbour N. C., Lorenz E., Schutte B. C., Zabner J., Kline J. N., Jones M., Frees K., Watt J. L., Schwartz D. A. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet. 2000 Jun;25(2):187–191. doi: 10.1038/76048. [DOI] [PubMed] [Google Scholar]
  3. Baldini M., Lohman I. C., Halonen M., Erickson R. P., Holt P. G., Martinez F. D. A Polymorphism* in the 5' flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E. Am J Respir Cell Mol Biol. 1999 May;20(5):976–983. doi: 10.1165/ajrcmb.20.5.3494. [DOI] [PubMed] [Google Scholar]
  4. Björkstén B., Naaber P., Sepp E., Mikelsaar M. The intestinal microflora in allergic Estonian and Swedish 2-year-old children. Clin Exp Allergy. 1999 Mar;29(3):342–346. doi: 10.1046/j.1365-2222.1999.00560.x. [DOI] [PubMed] [Google Scholar]
  5. Douwes J., Zuidhof A., Doekes G., van der Zee S. C., Wouters I., Boezen M. H., Brunekreef B. (1-->3)-beta-D-glucan and endotoxin in house dust and peak flow variability in children. Am J Respir Crit Care Med. 2000 Oct;162(4 Pt 1):1348–1354. doi: 10.1164/ajrccm.162.4.9909118. [DOI] [PubMed] [Google Scholar]
  6. Farooqi I. S., Hopkin J. M. Early childhood infection and atopic disorder. Thorax. 1998 Nov;53(11):927–932. doi: 10.1136/thx.53.11.927. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Gerrard J. W., Geddes C. A., Reggin P. L., Gerrard C. D., Horne S. Serum IgE levels in white and metis communities in Saskatchewan. Ann Allergy. 1976 Aug;37(2):91–100. [PubMed] [Google Scholar]
  8. Holt P. G., Sly P. D., Björkstén B. Atopic versus infectious diseases in childhood: a question of balance? Pediatr Allergy Immunol. 1997 May;8(2):53–58. doi: 10.1111/j.1399-3038.1997.tb00145.x. [DOI] [PubMed] [Google Scholar]
  9. Hunt L. W., Gleich G. J., Ohnishi T., Weiler D. A., Mansfield E. S., Kita H., Sur S. Endotoxin contamination causes neutrophilia following pulmonary allergen challenge. Am J Respir Crit Care Med. 1994 Jun;149(6):1471–1475. doi: 10.1164/ajrccm.149.6.8004300. [DOI] [PubMed] [Google Scholar]
  10. Liu A. H., Leung D. Y. Modulating the early allergic response with endotoxin. Clin Exp Allergy. 2000 Nov;30(11):1536–1539. doi: 10.1046/j.1365-2222.2000.01012.x. [DOI] [PubMed] [Google Scholar]
  11. MacDonald T. T., Carter P. B. Requirement for a bacterial flora before mice generate cells capable of mediating the delayed hypersensitivity reaction to sheep red blood cells. J Immunol. 1979 Jun;122(6):2624–2629. [PubMed] [Google Scholar]
  12. Martinez F. D. Maturation of immune responses at the beginning of asthma. J Allergy Clin Immunol. 1999 Mar;103(3 Pt 1):355–361. doi: 10.1016/s0091-6749(99)70456-2. [DOI] [PubMed] [Google Scholar]
  13. Michel O., Ginanni R., Duchateau J., Vertongen F., Le Bon B., Sergysels R. Domestic endotoxin exposure and clinical severity of asthma. Clin Exp Allergy. 1991 Jul;21(4):441–448. doi: 10.1111/j.1365-2222.1991.tb01684.x. [DOI] [PubMed] [Google Scholar]
  14. Michel O., Ginanni R., Sergysels R. Protective effect of sodium cromoglycate on lipopolysaccharide-induced bronchial obstruction in asthmatics. Int Arch Allergy Immunol. 1995 Nov;108(3):298–302. doi: 10.1159/000237168. [DOI] [PubMed] [Google Scholar]
  15. Michel O., Olbrecht J., Moulard D., Sergysels R. Effect of anti-asthmatic drugs on the response to inhaled endotoxin. Ann Allergy Asthma Immunol. 2000 Oct;85(4):305–310. doi: 10.1016/S1081-1206(10)62534-3. [DOI] [PubMed] [Google Scholar]
  16. Nightingale J. A., Rogers D. F., Hart L. A., Kharitonov S. A., Chung K. F., Barnes P. J. Effect of inhaled endotoxin on induced sputum in normal, atopic, and atopic asthmatic subjects. Thorax. 1998 Jul;53(7):563–571. doi: 10.1136/thx.53.7.563. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Poltorak A., He X., Smirnova I., Liu M. Y., Van Huffel C., Du X., Birdwell D., Alejos E., Silva M., Galanos C. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science. 1998 Dec 11;282(5396):2085–2088. doi: 10.1126/science.282.5396.2085. [DOI] [PubMed] [Google Scholar]
  18. Pulverer G., Ko H. L., Beuth J. Effets immunomodulateurs des antibiotiques influençant les flores digestives. Pathol Biol (Paris) 1993 Oct;41(8 Pt 2):753–758. [PubMed] [Google Scholar]
  19. Sandström T., Bjermer L., Rylander R. Lipopolysaccharide (LPS) inhalation in healthy subjects increases neutrophils, lymphocytes and fibronectin levels in bronchoalveolar lavage fluid. Eur Respir J. 1992 Sep;5(8):992–996. [PubMed] [Google Scholar]
  20. Sepp E., Julge K., Vasar M., Naaber P., Björksten B., Mikelsaar M. Intestinal microflora of Estonian and Swedish infants. Acta Paediatr. 1997 Sep;86(9):956–961. doi: 10.1111/j.1651-2227.1997.tb15178.x. [DOI] [PubMed] [Google Scholar]
  21. Strachan D. P. Family size, infection and atopy: the first decade of the "hygiene hypothesis". Thorax. 2000 Aug;55 (Suppl 1):S2–10. doi: 10.1136/thorax.55.suppl_1.s2. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Strachan D. P. Hay fever, hygiene, and household size. BMJ. 1989 Nov 18;299(6710):1259–1260. doi: 10.1136/bmj.299.6710.1259. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Sudo N., Sawamura S., Tanaka K., Aiba Y., Kubo C., Koga Y. The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction. J Immunol. 1997 Aug 15;159(4):1739–1745. [PubMed] [Google Scholar]
  24. Thorn J., Rylander R. Inflammatory response after inhalation of bacterial endotoxin assessed by the induced sputum technique. Thorax. 1998 Dec;53(12):1047–1052. doi: 10.1136/thx.53.12.1047. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Van Vlem B., Vanholder R., De Paepe P., Vogelaers D., Ringoir S. Immunomodulating effects of antibiotics: literature review. Infection. 1996 Jul-Aug;24(4):275–291. doi: 10.1007/BF01743360. [DOI] [PubMed] [Google Scholar]
  26. Wickens K., Pearce N., Crane J., Beasley R. Antibiotic use in early childhood and the development of asthma. Clin Exp Allergy. 1999 Jun;29(6):766–771. doi: 10.1046/j.1365-2222.1999.00536.x. [DOI] [PubMed] [Google Scholar]

Articles from Mediators of Inflammation are provided here courtesy of Wiley

RESOURCES