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. 1998;7(3):169–173. doi: 10.1080/09629359891108

Somatostatin does not attenuate intestinal injury in dextran sodium sulphate-induced subacute colitis.

J D van Bergeijk 1, M E van Meeteren 1, C J Tak 1, A P van Dijk 1, M A Meijssen 1, J H Wilson 1, F J Zijlstra 1
PMCID: PMC1781842  PMID: 9705604

Abstract

FRom several in vitro and in vivo studies involvement of somatostatin (SMS) in intestinal inflammation emerge. Acute colitis induced in rats is attenuated by the long-acting SMS analogue octreotide. We studied the potential beneficial effect of SMS on non-acute experimental colitis. BALB/c mice received either saline, SMS-14 (36 or 120 microg daily) or octreotide (3 microg daily) subcutaneously delivered by implant osmotic pumps. A non-acute colitis was induced by administration of dextran sodium sulphate (DSS) 10% in drinking water during 7 days. DSS evoked a mild, superficial pancolitis, most characterized by mucosal ulceration and submucosal influx of neutrophils. Neither SMS-14 nor octreotide reduced mucosal inflammatory score or macroscopical disease activity, although reduction of intestinal levels of interleukin-1beta (IL-1beta), IL-6 and IL-10 during DSS was augmented both by SMS and octreotide. A slight increase of neutrophil influx was seen during SMS administration in animals not exposed to DSS. In conclusion, SMS or its long-acting analogue did not reduce intestinal inflammation in non-acute DSS-induced colitis. According to the cytokine profile observed, SMS-14 and octreotide further diminished the reduction of intestinal macrophage and Th2 lymphocyte activity.

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Selected References

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  1. Binimelis J., Webb S. M., Monés J., Serrano J., Casamitjana R., Elena M., Peinado M. A., Vilardell F., De Leiva A. Circulating immunoreactive somatostatin in gastrointestinal diseases. Decrease after vagotomy and enhancement in active ulcerative colitis, irritable bowel syndrome, and duodenal ulcer. Scand J Gastroenterol. 1987 Oct;22(8):931–937. doi: 10.3109/00365528708991938. [DOI] [PubMed] [Google Scholar]
  2. Björck S., Jennische E., Dahlström A., Ahlman H. Influence of topical rectal application of drugs on dextran sulfate-induced colitis in rats. Dig Dis Sci. 1997 Apr;42(4):824–832. doi: 10.1023/a:1018880501437. [DOI] [PubMed] [Google Scholar]
  3. Blum A. M., Metwali A., Mathew R. C., Cook G., Elliott D., Weinstock J. V. Granuloma T lymphocytes in murine schistosomiasis mansoni have somatostatin receptors and respond to somatostatin with decreased IFN-gamma secretion. J Immunol. 1992 Dec 1;149(11):3621–3626. [PubMed] [Google Scholar]
  4. Cooper H. S., Murthy S. N., Shah R. S., Sedergran D. J. Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest. 1993 Aug;69(2):238–249. [PubMed] [Google Scholar]
  5. Dieleman L. A., Ridwan B. U., Tennyson G. S., Beagley K. W., Bucy R. P., Elson C. O. Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice. Gastroenterology. 1994 Dec;107(6):1643–1652. doi: 10.1016/0016-5085(94)90803-6. [DOI] [PubMed] [Google Scholar]
  6. Domek M. J., Iwata F., Blackman E. I., Kao J., Baker M., Vidrich A., Leung F. W. Anti-neutrophil serum attenuates dextran sulfate sodium-induced colonic damage in the rat. Scand J Gastroenterol. 1995 Nov;30(11):1089–1094. doi: 10.3109/00365529509101612. [DOI] [PubMed] [Google Scholar]
  7. Dorta G., Schnegg J. F., Saraga E., Schmied P. A. Treatment of gold-induced enteritis with octreotide. Lancet. 1993 Jul 17;342(8864):179–179. doi: 10.1016/0140-6736(93)91386-z. [DOI] [PubMed] [Google Scholar]
  8. Dziarski R. Synergistic enhancement of T cell responses and interleukin-1 receptor expression by interleukin-1 and heparin or dextran sulfate. Cell Immunol. 1992 Nov;145(1):100–110. doi: 10.1016/0008-8749(92)90316-h. [DOI] [PubMed] [Google Scholar]
  9. Eliakim R., Karmeli F., Okon E., Rachmilewitz D. Octreotide effectively decreases mucosal damage in experimental colitis. Gut. 1993 Feb;34(2):264–269. doi: 10.1136/gut.34.2.264. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Elliott D. E., Weinstock J. V. Granulomas in murine schistosomiasis mansoni have a somatostatin immunoregulatory circuit. Metabolism. 1996 Aug;45(8 Suppl 1):88–90. doi: 10.1016/s0026-0495(96)90093-1. [DOI] [PubMed] [Google Scholar]
  11. Elson C. O., Sartor R. B., Tennyson G. S., Riddell R. H. Experimental models of inflammatory bowel disease. Gastroenterology. 1995 Oct;109(4):1344–1367. doi: 10.1016/0016-5085(95)90599-5. [DOI] [PubMed] [Google Scholar]
  12. Koch T. R., Carney J. A., Morris V. A., Go V. L. Somatostatin in the idiopathic inflammatory bowel diseases. Dis Colon Rectum. 1988 Mar;31(3):198–203. doi: 10.1007/BF02552546. [DOI] [PubMed] [Google Scholar]
  13. Miller S. K., Martindale R. G., Gao X. X., Gadacz T. R. The effects of octreotide on healing of small bowel anastomosis. Am Surg. 1996 Sep;62(9):733–737. [PubMed] [Google Scholar]
  14. Minocha A., Thomas C., Omar R. Lack of crucial role of mast cells in pathogenesis of experimental colitis in mice. Dig Dis Sci. 1995 Aug;40(8):1757–1762. doi: 10.1007/BF02212698. [DOI] [PubMed] [Google Scholar]
  15. Mulvihill S. J., Pappas T. N., Fonkalsrud E. W., Debas H. T. The effect of somatostatin on experimental intestinal obstruction. Ann Surg. 1988 Feb;207(2):169–173. doi: 10.1097/00000658-198802000-00009. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Murthy S. N., Cooper H. S., Shim H., Shah R. S., Ibrahim S. A., Sedergran D. J. Treatment of dextran sulfate sodium-induced murine colitis by intracolonic cyclosporin. Dig Dis Sci. 1993 Sep;38(9):1722–1734. doi: 10.1007/BF01303184. [DOI] [PubMed] [Google Scholar]
  17. Ni J., Chen S. F., Hollander D. Effects of dextran sulphate sodium on intestinal epithelial cells and intestinal lymphocytes. Gut. 1996 Aug;39(2):234–241. doi: 10.1136/gut.39.2.234. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Okayasu I., Hatakeyama S., Yamada M., Ohkusa T., Inagaki Y., Nakaya R. A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology. 1990 Mar;98(3):694–702. doi: 10.1016/0016-5085(90)90290-h. [DOI] [PubMed] [Google Scholar]
  19. Partsch G., Matucci-Cerinic M. Effect of substance P and somatostatin on migration of polymorphonuclear (PMN) cells in vitro. Inflammation. 1992 Oct;16(5):539–547. doi: 10.1007/BF00918978. [DOI] [PubMed] [Google Scholar]
  20. Payer J., Huorka M., Duris I., Mikulecky M., Kratochvílová H., Ondrejka P., Lukác L. Plasma somatostatin levels in ulcerative colitis. Hepatogastroenterology. 1994 Dec;41(6):552–553. [PubMed] [Google Scholar]
  21. Stanisz A. M. Neuroimmunomodulation in the gastrointestinal tract. Ann N Y Acad Sci. 1994 Nov 25;741:64–72. doi: 10.1111/j.1749-6632.1994.tb23086.x. [DOI] [PubMed] [Google Scholar]
  22. Thompson J. S., Nguyen B. L., Harty R. F. Somatostatin analogue inhibits intestinal regeneration. Arch Surg. 1993 Apr;128(4):385–389. doi: 10.1001/archsurg.1993.01420160023002. [DOI] [PubMed] [Google Scholar]
  23. Watanabe T., Kubota Y., Sawada T., Muto T. Distribution and quantification of somatostatin in inflammatory disease. Dis Colon Rectum. 1992 May;35(5):488–494. doi: 10.1007/BF02049408. [DOI] [PubMed] [Google Scholar]
  24. Wiedermann C. J., Reinisch N., Braunsteiner H. Stimulation of monocyte chemotaxis by human growth hormone and its deactivation by somatostatin. Blood. 1993 Aug 1;82(3):954–960. [PubMed] [Google Scholar]
  25. Yamamoto H., Morise K., Kusugami K., Furusawa A., Konagaya T., Nishio Y., Kaneko H., Uchida K., Nagai H., Mitsuma T. Abnormal neuropeptide concentration in rectal mucosa of patients with inflammatory bowel disease. J Gastroenterol. 1996 Aug;31(4):525–532. doi: 10.1007/BF02355052. [DOI] [PubMed] [Google Scholar]
  26. van Hagen P. M., Krenning E. P., Kwekkeboom D. J., Reubi J. C., Anker-Lugtenburg P. J., Löwenberg B., Lamberts S. W. Somatostatin and the immune and haematopoetic system; a review. Eur J Clin Invest. 1994 Feb;24(2):91–99. doi: 10.1111/j.1365-2362.1994.tb00972.x. [DOI] [PubMed] [Google Scholar]

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