Figure 4.

Lymph nodes tissue showing the staining pattern of Fas ligand (FasL), Fas, and caspase 3 for detecting apoptotic cells, Bax, and Bcl-2 in the tuberculosis granulomas, as detected by immunohistochemical staining. (a) Low power view; the marked area is shown at high power in (b). The epithelioid cells and the giant cells expressed FasL, Fas and Bax. In 54% of cases, the necrotic centres (NC) expressed high levels of FasL, but Fas expression was absent or weak. Bcl-2-expressing cells were very few or could not be detected in the granulomas, whereas the surrounding lymphoid tissue expressed Bcl-2 strongly.