Table 2. Proportion of MZMφ-area in the splenic MZ of mice pretreated with various antibodies.
5 mg/kg 24hr | |||
---|---|---|---|
LPS Time Antibody | Isotype | anti-TNF-α | anti-IL-10 |
Tgm (%) | 36·1 ± 12·9* | 70·7 ± 2·9† | 36·8 ± 1·1* |
Non-Tgm (%) | 82·5 ± 1·4 | 76·1 ± 3·0 | 71·7 ± 5·9 |
ER-TR9 positive area was measured from at least 10 sections of the spleen per mouse using NIH Image Software. Data represent the mean±SEM for three mice per group.
Significantly smaller than non-Tgm (P<0·05).
Significantly larger than isotype-control Tgm group (P<0·05).